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Glutamine 57 at the Complementary Binding Site Face Is a Key Determinant of Morantel Selectivity for α7 Nicotinic Receptors
(American Society for Biochemistry and Molecular Biology, 2009-08)
Nicotinic receptors (AChRs) play key roles in synaptic transmission. We explored activation of neuronal alpha7 and mammalian muscle AChRs by morantel and oxantel. Our results revealed a novel action of morantel as a ...
Estudos de modelagem molecular de compostos bioativos frente ao receptor nicotínico de acetilcolina do subtipo alfa4beta2
(Universidade Estadual Paulista (Unesp), 2016)
Neuronal nicotinic acetylcholine receptors (nAChRs) are pentameric transmembrane ion channels located in the central nervous system (CNS) that open and allow the flow of some ions through the action of the endogenous ...
The Cholinergic Lateral Line Efferent Synapse: Structural, Functional and Molecular Similarities With Those of the Cochlea
(Frontiers Media, 2021-10)
Vertebrate hair cell (HC) systems are innervated by efferent fibers that modulate their response to external stimuli. In mammals, the best studied efferent-HC synapse, the cholinergic medial olivocochlear (MOC) efferent ...
Is the antidepressant activity of selective serotonin reuptake inhibitors mediated by nicotinic acetylcholine receptors?
(Molecular Diversity Preservation International, 2021-04)
It is generally assumed that selective serotonin reuptake inhibitors (SSRIs) induce antidepressant activity by inhibiting serotonin (5-HT) reuptake transporters, thus elevating synaptic 5-HT levels and, finally, ameliorates ...
Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation: Role of α7 nicotinic receptor, glutamate and oxidative stress
(Elsevier Science, 2018-07)
Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms ...
Positive modulators of the α7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer's disease
(2016-09-01)
Evidence so far indicates that therapies targeting a single aspect of Alzheimer's disease (AD) have no sufficient efficacy in diminishing long-term the progression of AD. Neuroinflammation is an early event during the ...
Functional and structural interaction of (-)-lobeline with human α4β2 and α4β4 nicotinic acetylcholine receptor subtypes
(Pergamon-Elsevier Science Ltd, 2015)
Differential Pharmacological Activity of JN403 between á7 and Muscle Nicotinic Acetylcholine Receptors
(American Chemical Society, 2013-10)
The differential action of the novel agonist JN403 at neuronalα7 and muscle nicotinic receptors (AChRs)was explored by using a combination of functional and structural approaches. Single-channel recordings reveal that JN403 ...
Contribution of subunits to Caenorhabditis elegans levamisole-sensitive nicotinic receptor function
(American Society for Pharmacology and Experimental Therapeutics, 2012-09-25)
Caenorhabditis elegans muscle contains seven different nicotinic receptor (AChR) subunits, five of which have been shown to be components of adult levamisole-sensitive AChRs (L-AChRs). To elucidate the reason for such ...