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Central nervous system activities of two diterpenes isolated from Aloysia virgata
(Elsevier Gmbh, 2011-03)
Using the guide of a competitive assay for the benzodiazepine binding site in the γ-aminobutyric acid type A receptor (GABAA), two active diterpenes were isolated from the aerial parts of Aloysia virgata (Ruíz & Pavón) ...
Two rhodamine 6G derivative compounds: A structural and fluorescence single-crystal study
(International Union of Crystallography, 2016-10)
The synthesis, characterization, structural analysis and fluorescence properties of two rhodamine 6G derivatives are described, namely a propargylamine derivative, 3′,6′-bis(ethylamino)-2′,7′-dimethyl-2-(methylcyanide)sp ...
Synthesis and pharmacological evaluation of pyrazolo[4,3-c]quinolinones as high affinity GABAA-R ligands and potential anxiolytics
(Pergamon-Elsevier Science Ltd, 2018-08)
The synthesis, in vitro ligand binding study and in vivo Elevated Plus Maze test (EPM) of a series of pyrazolo[4,3-c]quinolin-3-ones (PQs) are reported. Multistep synthesis of PQs started from anilines and diethyl ...
Synthesis and pharmacological evaluation of pyrazolo[4,3-c]quinolinones as high affinity GABAA-R ligands and potential anxiolytics
(Elsevier, 2018-08-07)
The synthesis, in vitro ligand binding study and in vivo Elevated Plus Maze test (EPM) of a series of pyrazolo[4,3-c]quinolin-3-ones (PQs) are reported. Multistep synthesis of PQs started from anilines and diethyl ...
GABAergic Regulation of Astroglial Gliotransmission through Cx43 Hemichannels
(2022)
Gamma-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain. It is produced by interneurons and recycled by astrocytes. In neurons, GABA activates the influx of Cl- via the GABAA receptor or ...
Análise de expressão gênica e metilação de DNA de pacientes em primeiro episódio psicótico virgens de tratamento
(Universidade Federal de São Paulo (UNIFESP), 2015-03-25)
A esquizofrenia é o transtorno mental mais grave e incapacitante dentre os distúrbios psiquiátricos. A demora em instituir tratamento adequado e a duração do primeiro episódio psicótico estão entre os principais fatores ...
NKCC1 and KCC2 protein expression is sexually dimorphic in the hippocampus and entorhinal cortex of neonatal rats
(2013)
Seizure susceptibility appears to be greater in males than females during the early developmental stages of the brain when the gamma-aminobutyric acid (GABA), acting through its GABA-A receptor, predominantly produces ...