Type 1 and type 2 diabetes mellitus (DM) are characterized by hyperglycemia, due to lost or damaged insulin-producing β-cells within the pancreatic islets of Langerhans. Rodent models of DM result in hyperglycemia, arising ...

1. 1. Streptozotocin-induced diabetes produced significant changes on the drug metabolizing enzyme machinery of rat kidney microsomes. 2. 2. It reduced the cytochrome P-450 content by 30%, this effect being reversed by ...

Microsomal lauric acid hydroxylation and fatty acid peroxisomal β-oxidation were studied in hepatic subcellulant preparations from streptozotocin-induced diabetic and diabetic insulin-treated rats. The liver microsomes of ...

The activities of the enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LD), creatine kinase (CK), amylase (AMS) and angiotensin converting enzyme ...

Studies of diabetes mellitus in the streptozotocin rat model suggest that sexual dysfunctions may result from diabetes-induced alterations of the neuroendocrine-reproductive tract axis. Our investigation was performed to ...

Neurotensin is a basic tridecapeptide which can act as a neuromodulator or a neurotransmitter and binds to a group of receptors. Neurotensin is able to inhibit Na+, K+-ATPase activity, an effect blocked by the presence of ...

Glucose metabolism and insulin signaling disruptions in the brain have been proposed as a likely etiology of Alzheimer's disease. The aim of the present study was to investigate the time course of cognitive impairments ...

The effects of using Bauhinia forficata leaf decoction (150 g leaf/l water; 35.2+/-7.8 ml/100 g body weight mean daily dose) as a drinking-water substitute for about I month on streptozotocin-diabetes (STZ-diabetes) in ...

Although several studies using peripheral blood samples suggest that DNA damage is caused by streptozotocin (STZ) per se, our hypothesis is that DNA damage is caused by STZ-induced glycemic changes. Thus, we aimed at ...