Now showing items 1-10 of 668
Prediction of Oncogenic Interactions and Cancer-Related Signaling Networks Based on Network Topology
(Public Library Science, 2013-10-25)
Cancer has been increasingly recognized as a systems biology disease since many investigators have demonstrated that this malignant phenotype emerges from abnormal protein-protein, regulatory and metabolic interactions ...
Macroautophagy and the oncogene-induced senescence
The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been ...
Oncogenic potential diverge among human papillomavirus type 16 natural variants
(ACADEMIC PRESS INC ELSEVIER SCIENCESAN DIEGO, 2012)
We compared E6/E7 protein properties of three different HPV-16 variants: AA. E-P and E-350G. Primary human foreskin keratinocytes (PHFK) were transduced with HPV-16 E6 and E7 and evaluated for proliferation and ability to ...
Combining immunotherapy with oncogene-targeted therapy: A new road for melanoma treatment
(Frontiers Research Foundation, 2015-02)
Cutaneous melanoma arises from the malignant transformation of skin melanocytes; its incidence and mortality have been increasing steadily over the last 50 years, now representing 3% of total tumors. Once melanoma metastasizes, ...
Image analysis of the AgNOR response in ras-transformed human breast epithelial cells
(Elsevier Gmbh, Urban & Fischer VerlagJenaAlemanha, 2008)
Kras oncogene analysis of non-melanoma skin tumors in Southeastern Brazil
Skin cancers are the most common human malignant neoplasia and their incidence is growing, chiefly in tropical countries. There is evidence that ultraviolet (UV) radiation present in sunlight is important for genetic damage. ...
Tumorogénesis y proteína mdm2
(Sociedad Médica de Santiago, 2000)
Spontaneous canine transmissible venereal tumor: association between different phenotypes and theinsertion LINE-1/c-myc
Objective: this study aimed to evaluate the LINE-1 transposon inserted in c-myc gene as a specific genetic alteration in cells of spontaneous canine Transmissible Venereal Tumor (TVT) with either lymphocytoid or plasmacytoid ...