Now showing items 1-10 of 512
Reactive oxygen species generated by NADPH oxidase are involved in neurodegeneration in the pilocarpine model of temporal lobe epilepsy
(ELSEVIER IRELAND LTD, 2010)
Reactive oxygen species (ROS) appear to be involved in several neurodegenerative disorders. We tested the hypothesis that oxidative stress could have a role in the hippocampal neurodegeneration observed in temporal lobe ...
Aminochrome as preclinical model for Parkinson's disease
(Impact Journals LLC, 2017)
Commentary: Gene therapy: A promising approach for neuroprotection in Parkinson’s disease?
(Frontiers Media S.A., 2017)
Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer
(Future Medicine Ltd., 2016)
Current strategies for brain diseases are mostly symptomatic and noncurative. Nanotechnology has the potential to facilitate the transport of drugs across the blood-brain barrier and to enhance their pharmacokinetic ...
Hormesis: Protecting neurons against cellular stress in Parkinson disease
(Taylor and Francis Inc., 2012)
Protein folding stress is a salient feature of the most frequent neurodegenerative diseases. Although the accumulation of abnormally folded proteins is a well-characterized event underlying the pathology, the way cells ...
Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson‘s disease
(Oxford University Press, 2008-12)
Parkinson's disease is a neurodegenerative disorder with uncertain aetiology and ill-defined pathophysiology. Activated microglial cells in the substantia nigra (SN) are found in all animal models of Parkinson's disease ...
Mitochondria and calcium regulation as basis of neurodegeneration associated with aging
(Frontiers Media S.A., 2018)
© 2018 Müller, Ahumada-Castro, Sanhueza, Gonzalez-Billault, Court and Cárdenas.Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several ...
Iron toxicity in neurodegeneration
Iron is an essential element for life on earth, participating in a plethora of cellular processes where one-electron transfer reactions are required. Its essentiality, coupled to its scarcity in aqueous oxidative environments, ...
Mitochondrial energy metabolism in neurodegeneration associated with methylmalonic acidemia
(SPRINGER/PLENUM PUBLISHERS, 2011)
Methylmalonic acidemia is one of the most prevalent inherited metabolic disorders involving neurological deficits. In vitro experiments, animal model studies and tissue analyses from human patients suggest extensive ...