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The role of mitochondrial DNA damage in the citotoxicity of reactive oxygen species
(SPRINGER/PLENUM PUBLISHERS, 2011)
Mitochondria contain their own genome, a small circular molecule of around 16.5 kbases. The mitochondrial DNA (mtDNA) encodes for only 13 polypeptides, but its integrity is essential for mitochondrial function, as all 13 ...
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
(Elsevier B.V., 2017-05-01)
We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and ...
Mitochondrial DNA 30-SNP data confirm high prevalence of African lineages in the population of Espirito Santo, Brazil
(2015-12-01)
Mitochondrial DNA (mtDNA) analysis is usually a last resort in routine forensic DNA casework especially when nuclear DNA analysis cannot be applied. Because of the Brazilian population is highly admixed it is necessary to ...
Evolution of the Metazoan Mitochondrial Replicase
(Oxford Univ Press, 2015-04-01)
The large number of complete mitochondrial DNA (mtDNA) sequences available for metazoan species makes it a good system for studying genome diversity, although little is known about the mechanisms that promote and/or are ...
Nuclear mitochondrial-like sequences in ants: Evidence from Atta cephalotes (Formicidae: Attini)
(2007-12-01)
Nuclear mitochondrial-like sequences (numts) are copies of mitochondrial DNA that have migrated to the genomic DNA. We present the first characterization of numts in ants, these numts being homologues to a mitochondrial ...
Leigh-like syndrome with the T8993G mutation in the mitochondrial ATPase 6 gene: long-term follow-up discloses a slowly progressive course
(ELSEVIER SCIENCE BV, 2009)
We describe the long-term clinical outcome of a patient with Leigh-like syndrome presenting as an early onset encephalopathy and peripheral neuropathy caused by the T8993G mutation in the mitochondrial DNA (mtDNA). Clinical ...
The complete mitochondrial genome sequence of Astyanax paranae (Teleostei: characiformes)
(Taylor & Francis Ltd, 2016-01-01)
Complete mitochondrial genome of the characiform fish Astyanax paranae was characterized in the present study. The whole mitogenome was 16,707 bp long and consisted of 13 protein-coding genes, 22 tRNAs, 2 rRNAs genes, a ...