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Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives
(Future Sci Ltd, 2018-09-01)
Aim: Considering the epidemiology of leishmaniasis, the emergence of resistant parasites to the approved drugs, and severe clinical manifestations, the development of novel leishmanicidal molecules has become of considerable ...
Leishmanicidal activity of biogenic Fe3O4 nanoparticles
(2017-12-01)
Due to the multiplicity of useful applications of metal oxide nanoparticles (ONPs) in medicine are growing exponentially, in this study, Fe3O4 (iron oxide) nanoparticles (IONPs) were biosynthesized using Rosemary to evaluate ...
Composition and leishmanicidal activity of the essential oil of Vernonia polyanthes Less (Asteraceae)
(2017-12-17)
The composition of the essential oil (EO) from leaves of Vernonia polyanthes and the evaluation of its leishmanicidal potential are reported here for the first time. The oil obtained by hydrodistillation was analysed by ...
Leishmanicidal activity of the crude extract, fractions and major piperidine alkaloids from the flowers of Senna spectabilis
(Elsevier B.V., 2014-02-15)
Senna spectabilis (sin. Cassia excelsa, C. spectabilis) is an endemic tree of South America and Africa, very common in Brazil, where it is known as canafistula-de-besouro and cassia-do-nordeste. In folk medicine, this plant ...
Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species
(Soc Brasileira FarmacognosiaJoao PessoaBrazil, 2012)
Leishmanicidal activity of Brosimum glaziovii (Moraceae) and chemical composition of the bioactive fractions by using high-resolution gas chromatography and GC-MS
(Sociedade Brasileira de Química, 2014-10-01)
As part of our ongoing SisBiota CNPq/FAPESP and Biota-FAPESP bioprospecting programs, this paper deals with the leishmanicidal properties of Brosimum glaziovii (Moraceae), and used gas chromatography analysis to determine ...
Synthesis, Antitubercular and Leishmanicidal Evaluation of Resveratrol Analogues
(Soc Brasileira Quimica, 2016-12-01)
In this paper we continue our efforts in the search for new Schiff bases as resveratrol analogues as promising antitubercular and antileishmanial agents. Compounds were evaluated in vitro against Mycobacterium tuberculosis ...
Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs
(Sociedade Brasileira de Medicina Tropical - SBMT, 2013-12-01)
Introduction Visceral leishmaniasis (VL) is caused by the intracellular protozoan Leishmania donovani complex. VL may be asymptomatic or progressive and is characterized by fever, anemia, weight loss and the enlargement ...
Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds
(Elsevier B. V., 2015-08-15)
Chalcones form a class of compounds that belong to the flavonoid family and are widely distributed in plants. Their simple structure and the ease of preparation make chalcones attractive scaffolds for the synthesis of a ...
Antibacterial and Leishmanicidal Activity of Bolivian Propolis
(Wiley Blackwell Publishing, Inc, 2016-01)
The antimicrobial activity of Bolivian propolis was assessed for the first time on a panel of bacteria and two endemic parasitic protozoa. Ten samples of Bolivian propolis and their main constituents were tested using the ...