Now showing items 1-10 of 1692
Microemulsões: Estrutura e aplicações como sistema de liberação de fármacos
Depending on formula composition, microemulsions may be used as a vehicle for drug administration. In this work the main applicable parameters used in the development of pharmaceutical microemulsions (ME) are analyzed. The ...
Farmacovigilância no Brasil: A relação entre polimorfismo de fármacos, efetividade e segurança dos medicamentos
In spite of the stated Brazilian policy on medicines that their quality, effectiveness and safety should be ensured at reasonable cost, hospitals in the ANVISA Surveillance Network have been receiving notifications of ...
Micellar modification of drug stability: analysis of the effect of hexadecyltrimethylammonium halides on the rate of degradation of cephaclor
The intra- and intermolecular rates of degradation of cephaclor were determined with and without hexadecyltrimethylammonium bromide (CTABr). Micellar-derived spectral shifts were used to measure the association of the ionic ...
Practical and regulatory considerations for stability-indicating methods for the assay of bulk drugs and drug formulations
As part of the overall analytical control strategy, current regulations require stability-indicating methods (SIMs) to demonstrate product integrity until the re-test period of drug substances (DSs) or throughout the shelf ...
ESTABILIDADE TERMICA DO PARACETAMOL EM SOLUCAO: CROMATOGRAFIA EM CAMADA DELGADA (CCD) - ESPECTROFOTOMETRIA ULTRAVIOLETA
The interference practised by the products in degradation of paracetemol when there is the application of spectrophotometry UV is the main obstruction to the execution of studies of thermic stability. The application of ...