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Reinforcing properties of fencamfamine: Involvement of dopamine and opioid receptors
(1995-01-17)
Fencamfamine (FCF) is a psychostimulant classified as an indirect dopamine agonist. The conditioning place preference (CPP) paradigm was used to investigate the reinforcing properties of FCF. After initial preferences had ...
Behavioral indices of moderate nigrostriatal 6–hydroxydopamine lesion: a preclinical Parkinson's model.
(1993-02)
Asymmetries in turning and scanning were investigated in rats with different degrees of neostriatal dopamine depletion after unilateral injections of 6-hydroxydopamine into the substantia nigra. Animals with severe lesions, ...
DAILY VARIATION IN PLASMA-CONCENTRATION OF FENCAMFAMINE AND STRIATAL DOPAMINE-RECEPTORS IN RATS
(Associação Brasileira de Divulgação Científica (ABRADIC), 1994-03-01)
Fencamfamine (FCF) is a psychostimulant drug classified as an indirect dopamine agonist. In the present study we evaluated the daily variation in plasma FCF concentration and in striatal dopamine receptors. Adult male ...
3-Chlorotyramine acting as ligand of the d2 dopamine receptor: molecular modeling, synthesis and d2 receptor affinity
(Wiley VCH Verlag, 2015-02)
We synthesized and tested 3-chlorotyramine as a ligand of the D2 dopamine receptor. This compound displayed a similar affinity by this receptor to that previously reported for dopamine. In order to understand further the ...
Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues
(2022-01-01)
Dopamine is an important neurotransmitter that regulates numerous essential functions, including cognition and voluntary movement. As such, it serves as an important scaffold for synthesis of novel analogues as part of ...
Hemiparkinsonian rats rotate toward the side with the weaker dopaminergic neurotransmission
(ELSEVIER SCIENCE BV, 2008)
Rats with unilateral lesion of the substantia nigra pars compacta (SNpc) have been used as a model of Parkinson`s disease. Depending on the lesion protocol and on the drug challenge, these rats rotate in opposite directions. ...
Involvement of dopamine receptors in diethylpropion-induced conditioning place preference
(Associação Brasileira de Divulgação Científica (ABRADIC), 1998-04-01)
Diethylpropion (DEP) is an amphetamine-like agent used as an anorectic drug. Abuse of DEP has been reported and some restrictions of its use have been recently imposed. The conditioning place preference (CPP) paradigm was ...
Activation of D1/5 Dopamine Receptors in the Dorsal Medial Prefrontal Cortex Promotes Incubated-Like Aversive Responses
(Frontiers Media S.A., 2017-10)
It is well established that neurons of the mammalian medial prefrontal cortex (mPFC) modulate different behavioral outputs, including several memory types. This behavioral modulation is, at least in part, under the control ...
Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex
(Elsevier, 2009-01)
Despite the tremendous importance of D1 and NMDA receptors to cognition (working memory, executive functions) and synaptic plasticity in the prefrontal cortex (PFC), little is known about the molecular mechanisms underlying ...