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Functional roles of T3.37 and S5.46 in the activation mechanism of the dopamine D1 receptor
(Springer Verlag, 2017)
© 2017, Springer-Verlag Berlin Heidelberg. The activation mechanism of dopamine receptors is unknown. The amino acids S5.42, S5.43, and S5.46 located in helix 5 appear to be crucial, but their specific roles in receptor ...
Theoretical study of dopamine. Application of the HSAB principle to the study of drug-receptor interactions
(Elsevier, 2000)
We present a theoretical conformational study of neutral and N- protonated form of dopamine in which we relate its pharmacological activity to the chemical hardness. We have found that the neutral form presents small ...
Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors
(Frontiers Media, 2020)
The strength of goal-oriented behaviors is regulated by midbrain dopamine neurons. Dysfunctions of dopaminergic circuits are observed in drug addiction and obsessive-compulsive disorder. Compulsive behavior is a feature ...
In vivo modulation of dopaminergic nigrostriatal pathways by cytisine derivatives: Implications for Parkinson's Disease
(2008)
Nicotinic acetylcholine receptor agonists are considered potential pharmacological agents for Parkinson's Disease treatment, due to their ability to improve experimental Parkinson symptomatology, reduce 3,4-dihydroxy-L-p ...
Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists
(2006)
Studies on the effect of dopaminergic agonists in behavioral measures of nociception have gathered numerous but rather conflicting data. We studied the effects of the D1/D2 receptor agonist apomorphine, as well as the ...
Structure-affinity relationships of halogenated predicentrine and glaucine derivatives at D1 and D2 dopaminergic receptors: Halogenation and D1 receptor selectivity
(Elsevier Ltd, 2005)
Halogenation of the aporphine alkaloid boldine at the 3-position leads to increased affinity for rat brain D1-like dopaminergic receptors with some selectivity over D2-like receptors. A series of 3-halogenated and ...
Modulation of Postnatal Neurogenesis by Perinatal Asphyxia: Effect of D1 and D2 Dopamine Receptor Agonists
(Springer New York LLC, 2017)
© 2016, Springer Science+Business Media New York. Perinatal asphyxia (PA) is associated to delayed cell death, affecting neurocircuitries of basal ganglia and hippocampus, and long-term neuropsychiatric disabilities. Several ...
Synthesis and Dopamine Receptor Selectivity of the Benzyltetrahydroisoquinoline, (R)-(+)-nor-Roefractine
(American Chemical Society and American Society of Pharmacognosy, 1998-01-15)
(R)-(+)-nor-Roefractine (1) was synthesized
by the Bischler-Napieralski route, using asymmetric
reduction of the 1,2-didehydro precursor imine with
sodium (S)-N-CBZ-prolinyloxyborohydride. Compound
1 was able to displace ...
Behavioral effects of triadimefon in zebrafish are associated with alterations of the dopaminergic and serotonergic pathways
(Elsevier, 2019)
Triadimefon (TDF) is a triazole fungicide extensively used in agriculture that has been found as a pollutant in numerous water sources. In mammals, it inhibits monoamine uptake through binding to the dopamine transporter, ...
Temporal summation in rat prefrontal pyramidal cells. Differential effects of pre- and postsynaptic neurochemical manipulations
(Elsevier, 1983)
The influence of both reserpine-induced depletion of catecolamines and chlorpromazine-induced blockade of dopamine receptors on integrative properties of rats prefrontal pyramidal cells was studied by evocating threshold ...