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De novo assembly and functional annotation of Myrciaria dubia fruit transcriptome reveals multiple metabolic pathways for L-ascorbic acid biosynthesis
(BioMed Central, 2015)
Background. Myrciaria dubia is an Amazonian fruit shrub that produces numerous bioactive phytochemicals, but is best known by its high L-ascorbic acid (AsA) content in fruits. Pronounced variation in AsA content has been ...
Immune Checkpoint Blockade via PD-L1 Potentiates More CD28-Based than 4-1BB-Based Anti-Carbonic Anhydrase IX Chimeric Antigen Receptor T Cells
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2023)
Eficácia, segurança e efetividade de inibidores de checkpoint imunológico para o câncer de pulmão de células não pequenas avançado ou metastático
(Universidade Federal de Minas GeraisBrasilMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIALPrograma de Pós-Graduação em Saúde PúblicaUFMG, 2020-02-14)
Introduction: cancer has become the main cause of premature mortality (before the age of 70) in one third of the countries. This phenomenon is related to the epidemiologic transition in 21st century. Among the world’s main ...
Targeted therapy to annihilate the immune-evading phenotype in cancer evolution
(Informa Healthcare, 2018-07)
Cancer is a moving target, and targeted therapy must ultimatelydeal with the evolution of the disease. This is becauseevolution is the substrate for development of resistance totargeted therapy. A successful therapeutic ...
A novel gene signature unveils three distinct immune-metabolic rewiring patterns conserved across diverse tumor types and associated with outcomes
(Frontiers Media, 2022)
Existing immune signatures and tumor mutational burden have only modest predictive capacity for the efficacy of immune check point inhibitors. In this study, we developed an immune-metabolic signature suitable for personalized ...
Screening of proteins related to the immunological checkpoint Lymphocyte activation gene-3 (LAG-3) through the BioID method
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2018)
MicroRNA modulated networks of adaptive and innate immune response in pancreatic ductal adenocarcinoma
(2019-05-01)
Despite progress in treatment strategies, only ~24% of pancreatic ductal adenocarcinoma (PDAC) patients survive >1 year. Our goal was to elucidate deregulated pathways modulated by microRNAs (miRNAs) in PDAC and Vater ...
Análise da expressão gênica de células pulmonares expostas à fumaça de cigarro
(Universidade Federal do Rio Grande do NorteBrasilUFRNBiomedicina, 2019-05-31)
Airway epithelial cells are the first cells of the lungs to be exposed to the toxic agents contained in cigarette smoke. Consequently, the response of these cells to cigarette smoke is of considerable interest since it is ...