Now showing items 1-10 of 100
A THEORETICAL STRUCTURE-AFFINITY RELATIONSHIP STUDY OF SOME CANNABINOID DERIVATIVES
(Sociedad Chilena de Química, 2008)
Retinal removal up-regulates cannabinoid CB1 receptors in the chick optic tectum
The endocannabinoid system has been implicated in several neurobiological processes, including neurodegeneration and neuro protection. The aim of this study was to evaluate the effects of unilateral retinal ablation on the ...
Expression analysis of cannabinoid receptors 1 and 2 in B cells during pregnancy and their role on cytokine production
(Elsevier Ireland, 2016-08)
The endocannabinoid system consists in a family of lipids that binds to and activates cannabinoid receptors. There are two receptors so far described, the cannabinoid receptor 1 (CB1) and 2 (CB2). In the context of pregnancy, ...
Endocannabinoid system in pregnancy
The endocannabinoid system (eCS), is a complex system, comprising the main endogenous ligands anandamide and 2-arachidonoyl glycerol, the cannabinoid receptors CB1 and CB2 and the biosynthetic and degrading enzymes. ...
Prenatal exposure to the CB1 and CB2 cannabinoid receptor agonist WIN 55,212-2 alters migration of early-born glutamatergic neurons and GABAergic interneurons in the rat cerebral cortex
The endocannabinoid system, composed of cannabinoid receptors, endocannabinoids, and synthesis and degradation enzymes, is present since early stages of brain development. During this period, the endocannabinoid system is ...
Endocannabinoids, Through Opioids And Prostaglandins, Contribute To Fever Induced By Key Pyrogenic Mediators
(ACADEMIC PRESS INC ELSEVIER SCIENCESAN DIEGO, 2016)
A theoretical structure-affinity relationship study of some cannabinoid derivatives
(SOC CHILENA QUIMICA, 2008-03)
A ZINDO/1 quantum-chemical structure-affinity relationship study with the KPG model is presented for the in vitro interaction of a group of classical, indole-derived and aminoalkylindole-derived cannabinoids with CB1 and ...
Mastering tricyclic ring systems for desirable functional cannabinoid activity
(Elsevier Masson, 2013-11)
There is growing interest in using cannabinoid receptor 2 (CB2) agonists for the treatment of neuropathic pain and other indications. In continuation of our ongoing program aiming for the development of new small molecule ...