Now showing items 1-10 of 231
External guide sequences targeting the aac(6')-Ib mRNA induce inhibition of amikacin resistance
(American Society for Microbiology, 2007-03)
The dissemination of AAC(6')-I-type acetyltransferases have rendered amikacin and other aminoglycosides all but useless in some parts of the world. Antisense technologies could be an alternative to extend the life of these ...
Atividade comparada da cefepima, cefpiroma e amicacina em amostras bacterianas hospitalares
The objective of this study was to evaluate the in vitro activity of cefepime, cefpirome and amikacin against the most prevalent nosocomial bacteria. Initially a prospective study was designed to compare the bacterial ...
Higher than recommended amikacin loading doses achieve pharmacokinetic targets without associated toxicity
Antibiotic therapy improves the outcome of severe sepsis and septic shock, however pharmacokinetic properties are altered in this scenario. Amikacin (AMK) is an option to treat community or nosocomial infections, although ...
Inhibition of aac(6')-Ib-mediated amikacin resistance by nuclease-resistant external guide sequences in bacteria
(National Academy of Sciences, 2009-07)
Inhibition of bacterial gene expression by RNase P-directed cleavage is a promising strategy for the development of antibiotics and pharmacological agents that prevent expression of antibiotic resistance. The rise in ...