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Alterações na linhagem celular e organização neuronal do giro denteado em dois modelos animais de epilepsia
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM NEUROCIÊNCIAS, 2017-08-30)
The granular cells of the hippocampus are one of the few types of neurons generated in the central nervous system of adult mammals. The current model of neurogenesis in the adult hippocampus assumes that neural stem cells ...
A trans-methylation mechanism between the two major H3K9 methyltransferases SETDB1 and SUV39H1 regulates heterochromatin establishment
(Universidad del RosarioDoctorado en Ciencias BiomédicasFacultad de Ciencias Naturales y Matemáticas, 2018)
Histone H3 lysine 9 trimethylation (H3K9me3) is a key epigenetic modification required for heterochromatin formation and maintenance, genome stability and silencing of transposable elements in embryonic stems cells (ESCs). ...
Identification of transcriptomic responses related to normal, healthy and accelerated aging
(Universidad del RosarioDoctorado en Ciencias BiomédicasFacultad de Ciencias Naturales y Matemáticas, 2018)
Aging is defined as the reduction in the physiological and adaptive capabilities of organisms with the passage of time. The accumulation of DNA damage could be the central event on which other factors related to the aging ...
Caracterización funcional del canal de potasio activado por calcio de conductancia intermedia (KCa3.1) en el endotelio de la córnea en condiciones fisiológicas y en ambientes hiperglúcidos
The cornea is the lens that protects the anterior surface of the eye and its transparent nature is a crucial part of the functioning of the eye. This characteristic is mainly determined by the activity of the cells of its ...
Autoantibody and environmental damage to the brain
(Universidad del RosarioDoctorado en Ciencias BiomédicasFacultad de Ciencias Naturales y Matemáticas, 2016)
Behavioral abnormalities and cognitive dysfunction may be present in patients with autoimmune diseases. The mechanisms that responsible for these neuropsychiatric manifestations are still largely unknown, however several ...