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Cancer pharmacogenetics: Study of genetically determined variations on cancer susceptibility due to xenobiotic exposure Farmacogenética del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióti
(2006)
Pharmacogenetics is the study of genetically determined variations in the response to drugs and toxic agents, and their implications on disease. Recently, the discipline has acquired great relevancy due to the development ...
ANTIOXIDANT PROPERTIES OF Rosmarinus officinalis AND ITS EFFECTS ON XENOBIOTIC BIOTRANSFORMATION
(Jose L. Martinez, 2009-11-30)
Rosmarinus officinalis (rosemary) extracts display antioxidant properties mainly due to the presence of polyphenols. These properties have yet to be systematically studied in biological systems. In this study, we used rat ...
Reactivity of the one-electron reduction product from nifedipine with relevant biological targets
(Elsevier Ireland Ltd, 1996)
The reactivity of the electrochemically generated nitro radical anion from nifedipine, a nitro aryl 1,4-dihydropyridine derivative, with relevant endobiotics and thiol-containing xenobiotics, was quantitatively assessed ...
Effect of DIMBOA, a hydroxamic acid from cereals, on peroxisomal and mitochondrial enzymes from aphids: Evidence for the presence of peroxisomes in aphids
(Kluwer Academic/Plenum Publishers, 1999)
2,4-Dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA), a hydroxamic acid involved in the resistance of cereals to aphids, was administered to adult individuals of the aphid Sitobion avenae in artificial diets. Effects on ...
High-affinity binding of fatty acyl-CoAs and peroxisome proliferator-CoA esters to glutathione S-transferases
(FEBS, 1999)
Acyl-CoAs are present at high concentrations within the cell, yet are strongly buffered by specific binding
proteins in order to maintain a low intracellular unbound acyl-CoA concentration, compatible with their
metabolic ...
A Mechanistic Model to Assess the Fate of Naphthalene and Benzo(a)pyrene in a Chilean WWTP
(MDPI, 2021)
Polycyclic aromatic hydrocarbons (PAHs) are a family of organic compounds of widespread
presence in the environment. They are recalcitrant, ubiquitous, prone to bioaccumulation, and
potentially carcinogenic. Effluent ...
An electrochemical evidence of free radicals formation from flutamide and its reactivity with endo/xenobiotics of pharmacological relevance
(ELSEVIER SCIENCE, 2001-01)
This paper reports the feasibility of free radicals formation from flutamide by using cyclic voltammetry. The electrochemical characteristics and the reactivity of the one-electron reduction product from flutamide in mixed ...
Evaluation of the antioxidant properties and effects on the biotransformation of commercial herbal preparations using rat liver endoplasmic reticulum
(2009)
The antioxidant herbal ingredients are xenobiotics for animals, many of them must be biotransformed to be eliminated, especially lipophilic compounds. Biotransformation of such xenobiotics- occurs mainly in the hepatic ...
Characterization of the cytochrome P450 monooxygenase genes (P450ome) from the carotenogenic yeast Xanthophyllomyces dendrorhous
(BIOMED Central Ltd., 2017)
Background: The cytochromes P450 (P450s) are a large superfamily of heme-containing monooxygenases involved in the oxidative metabolism of an enormous diversity of substrates. These enzymes require electrons for their ...
Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin
(1994)
The flavonoid silymarin and one of its structural components, silibinin, have been well characterized as hepato-protective substances. However, little is known about the biochemical mechanisms of action of these substances. ...