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Xeroderma pigmentosum: Low prevalence of germline XPA mutations in a brazilian XP population
(2015-04-01)
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by DNA repair defects that cause photophobia, sunlight-induced cancers, and neurodegeneration. Prevalence of germline mutations in the nucleotide ...
Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions
(ELSEVIER IRELAND LTDCLARE, 2012)
Doxorubicin (DOX) is an important tumor chemotherapeutic agent, acting mainly by genotoxic action. This work focus on cell processes that help cell survival, after DOX-induced DNA damage. In fact, cells deficient for XPA ...
The relative roles of DNA damage induced by UVA irradiation in human cells
(Royal Society of ChemistryCambridge, 2013-08)
UVA light (320–400 nm) represents approximately 95% of the total solar UV radiation that reaches the Earth’s surface. UVA light induces oxidative stress and the formation of DNA photoproducts in skin cells. These photoproducts ...
Sustained activation of p53 in confluent nucleotide excision repair-deficient cells resistant to ultraviolet-induced apoptosis
(ELSEVIER SCIENCE BV, 2008)
p53 activation is one of the main signals after DNA damage, controlling cell cycle arrest, DNA repair and apoptosis. We have previously shown that confluent nucleotide excision repair (NER)-deficient cells are more resistant ...
DNA damage induced by the anthracycline cosmomycin D in DNA repair-deficient cells
(SPRINGER, 2010)
Anthracyclines have been widely used as antitumor agents, playing a crucial role in the successful treatment of many types of cancer, despite some side effects related to cardiotoxicity. New anthracyclines have been designed ...
Gene Expression Profiles in Radiation Workers Occupationally Exposed to Ionizing Radiation
(JAPAN RADIATION RESEARCH SOC, 2009)
Ionizing radiation OR) imposes risks to human health and the environment. IR at low doses and low (lose rates has the potency to initiate carcinogenesis. Genotoxic environmental agents such as IR trigger a cascade of signal ...
Functional characterization of the putative Aspergillus nidulans DNA damage binding protein homologue DdbA
(SPRINGER, 2008)
Nucleotide excision repair (NER) eliminates helix-distorting DNA base lesions. Seven XP-deficient genetic complementation groups (XPA to XPG) have already been identified in mammals, and their corresponding genes have been ...
DNA damage induced Pol eta recruitment takes place independently of the cell cycle phase
(Landes Bioscience, 2009-10)
When DNA is damaged in cells progressing through S phase, replication blockage can be avoided by TLS (Translesion DNA synthesis). This is an auxiliary replication mechanism that relies on the function of specialized ...
Expression of oxidative stress and antioxidant defense genes in the kidney of inbred mice after intestinal ischemia and reperfusion
(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2013-12-01)
PURPOSE: To determine the gene expressions profile related to the oxidative stress and the antioxidant response in the kidneys of mice subjected to intestinal ischemia and reperfusion. METHODS: Twelve inbred mice (C57BL/6) ...