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Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions
(ELSEVIER IRELAND LTDCLARE, 2012)
Doxorubicin (DOX) is an important tumor chemotherapeutic agent, acting mainly by genotoxic action. This work focus on cell processes that help cell survival, after DOX-induced DNA damage. In fact, cells deficient for XPA ...
Modulação da expressão da proteína XPA em resposta ao tratamento com azul de metileno fotossensibilizado
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em BioquímicaBioquímica; Biologia Molecular, 2010-10-06)
Reactive oxygen species (ROS) are produced by aerobic metabolism and react with biomolecules, such as lipids, proteins and DNA. In high concentration, they lead to oxidative stress. Among ROS, singlet oxygen (1O2) is one ...
O papel da via de reparo por excisão de nucleotídeos na resposta celular ao estresse oxidativo e o estudo de alterações neuronais in vitro associadas a síndrome de Cockayne
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM BIOQUÍMICA, 2016-09-29)
In oxidative stress response, the base excision repair (BER) is
considered the major pathway for repair of oxidative lesions. However, an
increasing number of studies have indicated the role of nucleotide excision
(NER) ...
The relative roles of DNA damage induced by UVA irradiation in human cells
(Royal Society of ChemistryCambridge, 2013-08)
UVA light (320–400 nm) represents approximately 95% of the total solar UV radiation that reaches the Earth’s surface. UVA light induces oxidative stress and the formation of DNA photoproducts in skin cells. These photoproducts ...
Análise da expressão de APE1 após estresse oxidativo induzido em células proficientes e deficientes na via de reparo por excisão de nucleotídeos.
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em Ciências BiológicasBiodiversidade; Biologia Estrutural e Funcional., 2010-06-28)
Riboflavin is a vitamin very important in aerobic organisms, as a precursor of many coenzymes involved in the electron transporter chain. However, after photosensitization of riboflavin with UV or visible light, it generates ...
Sustained activation of p53 in confluent nucleotide excision repair-deficient cells resistant to ultraviolet-induced apoptosis
(ELSEVIER SCIENCE BV, 2008)
p53 activation is one of the main signals after DNA damage, controlling cell cycle arrest, DNA repair and apoptosis. We have previously shown that confluent nucleotide excision repair (NER)-deficient cells are more resistant ...
DNA damage induced by the anthracycline cosmomycin D in DNA repair-deficient cells
(SPRINGER, 2010)
Anthracyclines have been widely used as antitumor agents, playing a crucial role in the successful treatment of many types of cancer, despite some side effects related to cardiotoxicity. New anthracyclines have been designed ...
¿Cuáles son los beneficios que aportan las vitaminas D y C en la salud oral?
(El Mercurio, 2020-10-29)
Académico analiza el tema y entrega recomendaciones respecto a una correcta alimentación. La vitamina D tiene múltiples beneficios y es conocida comúnmente como la vitamina del sol. Pero ¿por qué es llamada así? Según los ...
Whole-Exome Sequencing Enables Rapid Determination of Xeroderma Pigmentosum Molecular Etiology
(Universidad del Rosario, 2013)
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder haracterized by extreme sensitivity to actinic pigmentation changes in the skin and increased incidence of skin cancer. In some cases, patients are affected ...
Gene Expression Profiles in Radiation Workers Occupationally Exposed to Ionizing Radiation
(JAPAN RADIATION RESEARCH SOC, 2009)
Ionizing radiation OR) imposes risks to human health and the environment. IR at low doses and low (lose rates has the potency to initiate carcinogenesis. Genotoxic environmental agents such as IR trigger a cascade of signal ...