Now showing items 1-10 of 515
Lindane-induced oxidative stress. I. Time course of changes in hepatic microsomal parameters, antioxidant enzymes, lipid peroxidative indices and morphological characteristics
(Informa Healthcare, 1988)
1. Lindane (60 mg/kg) administered orally to rats increased liver cytochrome P-450 content and superoxide radical (O- 2) generation 24 h after treatment, while formation of thiobarbituric acid reactants and NADPH/ADP-supported ...
Effects of diuron on toxicological and hematological parameters and lymphohematopoietic organs in a rat chemical hepatocarcinogenesis model
(Universidade Estadual Paulista (UNESP), 2005)
Dose-dependent effects of acute lindane treatment on Kupffer cell function assessed in the isolated perfused rat liver
1. Twenty-four hours after lindane exposure (5-60 mg/kg) a dose-dependent increase in the serum and hepatic levels of the insecticide was observed. Both the basal rate of O2 consumption and the sinusoidal efflux of lactate ...
The nematode Caenorhabditis elegans as an integrated toxicological tool to assess water quality and pollution
(Elsevier Science, 2016-11)
Determination of water quality status in rivers is critical to establish a sustainable water management policy. For this reason, over the last decades it has been recommended to perform integrated water assessments that ...
Effect of Carvedilol and Nebivolol on Oxidative Stress-related Parameters and Endothelial Function in Patients with Essential Hypertension
Oxidative stress and endothelial dysfunction have been associated with essential hypertension (EH) mechanisms. The purpose of this study was to evaluate the effect of carvedilol and nebivolol on the oxidative stress-related ...
Pharmacokinetics of a nitrofuran compound, nifurtimox, in healthy volunteers
Nifurtimox disposition was evaluated in 7 healthy volunteers. Each subject received an oral dose of 15 mg/kg of nifurtimox and blood sample was obtained 11 h after the drug administration. We used an analytical method ...
Influence of alcohol consumption on erythromycin ethylsuccinate kinetics
The effect of ethyl alcohol ingestion on erythromycin kinetics was studied. Nine healthy volunteers, four males and five females, participated in the study. They received, in two separate occasions, 500 mg of erythromycin ...
Water Quality and Toxicological Impact Assessment Using the Nematode Caenorhabditis elegans Bioassay in a Long-Term Intensive Agricultural Area
Due to intensive agricultural activities to meet the growing needs for food, large volumes of water are consumed and an increasing amount of agrochemicals are released into the environment threatening the aquatic ecosystem. ...
Efeitos do herbicida glifosate sobre o crescimento, enzimas digestivas e parâmetros toxicológicos em piavas (Leporinus sp.)
(Universidade Federal de Santa MariaBRZootecniaUFSMPrograma de Pós-Graduação em Zootecnia, 2005-08-26)
The effects of glyphosate (1.0 and 5.0 mg/L) on growth, digestive enzymes and toxicology parameters were evaluated in piavas (Leporinus sp.) after 90 days of exposure. A control group was kept in water without herbicide. ...