Now showing items 1-10 of 15
Toxicogenomics: new strategies for ecotoxicology studies in autochthonous species II : The 'omic' era in non-model species : Transcriptome analysis for biomarker screening
(Inderscience Enterprises, 2017-06)
The emerging field of ecotoxicogenomics aims to combine large-scale approaches to study the responses of organisms to a toxicant. A holistic vision of gene and protein expression in response to toxic exposure contributes ...
Relationship between head and neck cancer therapy and some genetic endpoints
(Baishideng Publishing Group Inc, 2014-05-10)
Head and neck cancer (HNC) is the sixth most common human malignancy worldwide. The main forms of treatment for HNC are surgery, radiotherapy (RT) and chemotherapy (CT). However, the choice of therapy depends on the tumor ...
Prediction of non-genotoxic carcinogenicity based on genetic profiles of short term exposure assays
(Korean Society of Toxicology, 2016-06)
Non-genotoxic carcinogens are substances that induce tumorigenesis by non-mutagenic mechanisms and long term rodent bioassays are required to identify them. Recent studies have shown that transcription profiling can be ...
Cell cycle kinetics, apoptosis rates and gene expressions of MDR-1, TP53, BCL-2 and BAX in transmissible venereal tumour cells and their association with therapy response
Transmissible venereal tumour (TVT) generally presents different degrees of aggressiveness, which makes them unresponsive to conventional treatment protocols. This implies a progressive alteration of their biological ...
Mechanisms Of In-stent Restenosis: A Toxicogenomic In Vitro Study Using Coronary Artery Endothelial And Smooth Muscle Cells
Toxicogenomic activity of gemcitabine in two TP53-mutated bladder cancer cell lines: special focus on cell cycle-related genes
Because of its lower toxicity and good tolerability and response, gemcitabine has been described as one of the most highly promising drugs for urinary bladder cancer therapy. Its phosphorylated active-dFdCTP metabolite can ...
Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status
(Indian Acad Sciences, 2017-03-01)
Silibinin is a natural phenol found in the seeds of the milk thistle plant. Recent data have shown its effectiveness for preventing/treating bladder tumours. Therefore, in this study we investigated the cytotoxic and ...
A COMPARATIVE STUDY OF TELLURITE TOXICITY IN NORMAL AND CANCER CELLS
(KOREAN SOCIETY OF TOXICOGENOMICS AND TOXICOPROTEOMICS, 2012)
Expression and promoter methylation status of two DNA repair genes in leukocytes from patients undergoing propofol or isoflurane anaesthesia
Despite the widespread use of the anaesthetics propofol (PROP) and isoflurane (ISO), data about their toxicogenomic potential and interference in epigenetic events are unknown. This study evaluated the expression and ...
Genotoxicity, cytotoxicity and gene expression in patients undergoing elective surgery under isoflurane anaesthesia
(Oxford University Press, 2011-05-01)
There are numerous studies reporting on the effects of inhalation anaesthesia in cells of exposed individuals but not much is known about the ability of isoflurane (ISF) to induce oxidative DNA damage. However, surgery is ...