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Assessing Tn5 and Sleeping Beauty for transpositional transgenesis by cytoplasmic injection into bovine and ovine zygotes

Bevacqua, Romina Jimena; Fernández y Martín, Rafael; Canel, Natalia Gabriela; Gibbons, A.; Texeira, D.; Lange, F.; Vans Landschoot, Geraldina; Savy, Virginia; Briski, Olinda; Hiriart MI; Grueso, E.; Ivics, Z.; Taboga, Oscar Alberto; Kues, W. A.; Ferraris, S.; Salamone, Daniel Felipe (Public Library of Science, 2017-03)

Transgenic domestic animals represent an alternative to bioreactors for large-scale production of biopharmaceuticals and could also provide more accurate biomedical models than rodents. However, their generation remains ...

Early fetal development of nuclear transfer bovine embryos generated from fibroblasts genetically modified by piggybac transposition

Alessio, Ana Paula; Fili, Alejandro; Forcato, Diego Oscar; Olmos Nicotra, Maria Florencia; Alustiza, Fabrisio Eduardo; Rodriguez, Natalia Evelin; Sampaio, R. V.; Sangalli, J.; Bressan, F.; Fantinato-Neto, P.; Meirelles, F.; Owens, J.; Moisyadi, S.; Kues, W.A.; Bosch, Pablo (Csiro Publishing, 2014-12-04)

Transposon-mediated transgenesis is a well-established tool for genome manipulation in small animal models. However, translation of this active transgenesis method to the large animal setting requires further investigation. ...