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Absence of TGF-beta RII predicts bone and lung metastasis and is associated with poor prognosis in stage III breast tumors
(IOS Press, 2012-01-01)
In the case of operated breast cancer (BC), prognostic markers help to determine if the patient needs additional treatment and predictive markers help the clinician to decide which treatment to use. Thus, a better knowledge ...
Absence of transforming growth factor-beta type II receptor is associated with poorer prognosis in HER2-negative breast tumours
(Oxford University Press, 2010-04-01)
Background: The clinical relevance of transforming growth factor-beta (TGF-beta)-signalling pathway in breast carcinomas (BCs) remained elusive. This study aimed to evaluate the prognostic value of TGF-beta and transforming ...
In vivo effects of TGF beta 1 on the the growth of gastric epithelium in suckling rats
(ELSEVIER SCIENCE BV, 2008)
As the content of Transforming Growth Factor-beta (TGF beta) wanes in the milk of lactating rat, an increase in TGF beta is observed in the gastric epithelia concomitant with differentiation of the glands upon weaning. ...
TGF-beta 1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells
(BIOMED CENTRAL LTDLONDON, 2012)
Background: Metastasis is the main factor responsible for death in breast cancer patients. Matrix metalloproteinases (MMPs) and their inhibitors, known as tissue inhibitors of MMPs (TIMPs), and the membrane-associated MMP ...
Regulation of galectin-1 expression by transforming growth factor beta1 in metastatic mammary adenocarcinoma cells: implications for tumor-immune escape
(Springer Verlag Berlín, 2007)
Tumors escape from immune surveillance by producing immunosuppressive cytokines and proapototic factors, including TGF-beta and galectin-1 (Gal-1). Since immunosuppressive mechanisms might act in concert to confer tumor-immune ...
Alteration on the expression of IL-1, PDGF, TGF-beta, EGF, and FGF receptors and c-Fos and c-Myc proteins in bone marrow mesenchymal stroma cells from advanced untreated lung and breast cancer patients.
(Mary Ann Liebert, Inc Publishers., 2005-12)
Previously, we reported a deficient cloning capacity of the bone marrow (BM) mesenchymal stem cells to give colony-forming unit fibroblast (CFU-F) and an inefficient confluence capacity of BM stromal cells in advanced ...
S-nitrosoglutathione Accelerates Recovery From 5-fluorouracil-induced Oral Mucositis
(Public Library of Science, 2014)