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Effects of rocuronium, sugammadex and rocuronium‐sugammadex complex on coagulation in ratsEfeitos do rocurônio, sugamadex e complexo rocurônio‐sugamadex sobre a coagulação em ratos
(2020-11-01)
Background and objectives: Sugammadex is an alternative pharmacological drug capable of reversing neuromuscular blockades without the limitations that are presented by anticholinesterase drugs. Coagulation disorders that ...
Pharmacokinetics and pharmacodynamics of rocuronium in young adult and elderly patients undergoing elective surgery
(2016-11-01)
Objective: To evaluate the impact of advanced age on rocuronium kinetic disposition in ASA I–III patients undergoing elective surgeries. Methods: Young adult (20–50 years, n = 15) and elderly patients (65–85 years, n = 14) ...
Effects of magnesium sulphate on the onset time of rocuronium at different doses: a randomized clinical trial
(2021-09-01)
Background and aims: Rocuronium may provide excellent onset time, but high doses are required for effective action. Several strategies have managed to shorten rocuronium onset time, including the use of Magnesium Sulphate ...
The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries
(2017-08-01)
Purpose: Rocuronium (ROC) is a neuromuscular blocker mainly eliminated by biliary excretion dependent on organic anion transporting polypeptide 1A2 (OATP1A2) hepatocellular uptake. However, the influence of SLCO1A2 (gene ...
Analysis of rocuronium in human plasma by liquid chromatography-tandem mass spectrometry with application in clinical pharmacokinetics
(Elsevier B.V., 2014-03-05)
Rocuronium (ROC) is a neuromuscular blocking agent used in surgical procedures which is eliminated primarily by biliary excretion. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated ...
Tempo de latencia do rocuronio e da succinilcolina e condicoes de intubacao traqueal
(1997-10-15)
Background and Objectives - Pulmonary aspiration of gastric content during induction of anesthesia for emergency surgical procedures is a serious complication; fast endotracheal intubation under these circumstances is of ...
Tempo de latencia e duracao do efeito do brometo de rocuronio no paciente submetido ao transplante renal
(2000-01-01)
Background and Objectives - Successful cadaver kidney transplantation relies on a fast procedure. Patients with chronic renal failure may present with a delayed gastric emptying making it critical a fast tracheal intubation ...