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Molecular characterization of IPNV RNA replication intermediates during the viral infective cycle
Infectious Pancreatic Necrosis Virus (IPNV) is a bisegmented, double-stranded RNA virus, which belongs to the Birnaviridae family. In the current study, we have analyzed the RNA replication intermediates (RI) purified ...
Antiviral activity of phosphonoformate on rotavirus transcription and replication
The antiviral effect of foscarnet (PFA) on the replication of rotavirus, a member of the Reoviridae, was studied. The pyrophosphate analogue is an effective inhibitor of several viral polymerases acting on the enzyme ...
Plant chromatin replicated in the absence of protein synthesis
The aim of the present work is to detect possible differences in the chromatin of plants replicated in the absence of protein synthesis.The kinetics of nuclease digestion in Allium cepa L., evaluated after making the cells ...
FBH1 mediates DNA double strand breakage and apoptosis in response to DNA replication stress
(Rockefeller Univ Press, 2013-01)
Proper resolution of stalled replication forks is essential for genome stability. Purification of FBH1, a UvrD DNA helicase, identified a physical interaction with replication protein A (RPA), the major cellular singlestranded ...