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Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine
(2005-10-01)
Purine nucleoside phosphorylase (PNP) catalyzes the reversible phosphorolysis of nucleosides and deoxynucleosides, generating ribose 1-phosphate and the purine base, which is an important step of purine catabolism pathway. ...
Docking and small angle X-ray scattering studies of purine nucleoside phosphorylase
(Elsevier B.V., 2003-10-03)
Docking simulations have been used to assess protein complexes with some success. Small angle X-ray scattering (SAXS) is a well-established technique to investigate protein spatial configuration. This work describes the ...
Purine nucleoside phosphorylase from Schistosoma mansoni in complex with ribose-1-phosphate
(WILEY-BLACKWELL PUBLISHING, INC, 2011)
Schistosomes are blood flukes which cause schistosomiasis, a disease affecting approximately 200 million people worldwide. Along with several other important human parasites including trypanosomes and Plasmodium, schistosomes ...
Crystal structure of Schistosoma purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor
(ELSEVIER SCIENCE BV, 2010)
A novel inhibitor of Schistosoma PNP was identified using an ""in silico"" approach allied to enzyme inhibition assays. The compound has a monocyclic structure which has not been previously described for PNP inhibitors The ...
Purine nucleoside phosphorylase: A potential target for the development of drugs to treat T-cell- and apicomplexan parasite-mediated diseases
(Bentham Science Publ Ltd, 2007-03-01)
Purine nucleoside phosphorylase (PNP) catalyzes the reversible phosphorolysis of nucleosides and deoxynucleosides, generating ribose 1-phosphate and the purine base, which is an important step of purine catabolism pathway. ...
Cloning, overexpression, and purification of functional human purine nucleoside phosphorylase
(2003-01-01)
Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides. A genetic deficiency due to mutations in the gene encoding for human PNP causes T-cell ...