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Backbone Flexibility Controls the Activity and Specificity of a Protein−Protein Interface: Specificity in Snake Venom Metalloproteases
(2010-07-09)
Protein-protein interfaces have crucial functions in many biological processes. The large interaction areas of such interfaces show complex interaction motifs. Even more challenging is the understanding of (multi)specificity ...
Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis
(2016-04-01)
The time-course of the pathological effects induced by the venom of the snake Bothrops asper in muscle tissue was investigated by a combination of histology, proteomic analysis of exudates collected in the vicinity of ...
Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage
(2015-04-24)
Snake venom hemorrhagic metalloproteinases (SVMPs) of the PI, PII and PIII classes were
compared in terms of tissue localization and their ability to hydrolyze basement membrane
components in vivo, as well as by a ...
Myotoxin II from Bothrops asper (Terciopelo) venom is a lysine-49 phospholipase A2
(1991)
A basic, dimeric myotoxic protein, myotoxin II, purified from Bothrops asper venom has a similar molecular weight and is immunologically cross-reactive with antibodies raised to previously isolated B. asper phospholipases ...
Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii
(2016-06)
Snake venoms are composed mainly of a mixture of proteins and peptides. Notably, all snake venom toxins have been assigned to a small number of protein families. Proteomic studies on snake venoms have recently identified ...
Using the Protein Leverage Hypothesis to understand socioeconomic variation in obesity
(2017-01-25)
The protein leverage hypothesis (PLH) predicts that protein appetite will
stimulate excess energy intake, and consequently obesity, when the proportion of
protein in the diet is low. Experimental studies support the PLH, ...
Inflammatory infiltrate in skeletal muscle injected with Bothrops asper venom
(1986)
The time-course and composition of inflammatory infiltrate in mouse gastrocnemius injected with Bothrops asper venom was studied. The venom induced myonecrosis, and a prominent decrease in muscle levels of creatine kinase ...
Resurrexit, sicut dixit, alleluia. Snake venomics from a 26-years old polyacrylamide focusing gel
(2012)
A 26-year-old dried polyacrylamide gel, cast in presence of an immobilized pH gradient and
containing focused proteins from the venoms of a northern black-tailed rattlesnake (Crotalus
molossus molossus), and of a western ...
Elapid venom toxins: multiple recruitments of ancient scaffolds
(1999-01)
Nigroxins A and B, two myotoxic phospholipases A2 (PLA2s) from the venom of the American elapid Micrurus nigrocinctus, belong to a new PLA2 subclass. Their primary structures were established and compared with those of ...
Proteoform-resolved quantitative venomics: looking through a crystal ball
(2017-04)
In this paper we discuss recent significant developments in the field of venom research, specifically the emergence
of top-down proteomic applications that allow achieving compositional resolution at the level of the ...