Buscar
Mostrando ítems 1-10 de 98
Can pharmacogenetics explain efficacy and safety of cisplatin pharmacotherapy?
(Frontiers Media S.A., 2014)
© 2014 Roco, Cayún, Contreras, Stojanova and Quiñones.Several recent pharmacogenetic studies have investigated the variability in both outcome and toxicity in cisplatin-based therapies. These studies have focused on the ...
Pharmacogenetics, tobacco, alcohol and its effect on the risk development cancer Farmacogenética, tabaco, alcohol y su efecto sobre el riesgo de desarrollar cáncer
(Sociedad Chilena de Pediatria, 2018)
© 2018, Sociedad Chilena de Pediatria. All rights reserved. Cancer is the second leading cause of death in the world, causing 8.8 million deaths in 2015 according to the World Health Organization (WHO). Risk factors for ...
Uses and misuses of definitions of genetic polymorphism: A perspective from population pharmacogenetics
(1991)
Definitions of genetic polymorphism currently employed
in the pharmacological literature have been incorrectly
used (Kalow, 1984) and uncritically imported from
population genetics [e.g., Weinshilboum (1984), Evans
(1977)], ...
Growth Hormone Receptor Exon 3 Isoforms and Their Implication in Growth Disorders and Treatment
(KARGER, 2009)
Human recombinant growth hormone (hGH) has been used to treat short stature in several different conditions, but considerable inter-individual variation in short- and long-term growth response exists. Pharmacogenomics can ...
Pharmacogenomics in chronic pain therapy: From disease to treatment and challenges for clinical practice
(2019-01-01)
Pharmacogenomics (PGx) has emerged as an encouraging tool in chronic pain therapy. Genetic variations associated with drug effectiveness or adverse reactions (amitriptyline/nortriptyline/codeine/oxycodone/tramadol-CYP2D6, ...
Pharmacogenetic studies in children with acute lymphoblastic leukemia in Argentina
(Taylor & Francis Ltd, 2014-08)
The aim of this study was to evaluate the influence of the most common genetic variants in methylenetetrahydrofolate reductase (MTHFR), thiopurine methyltransferase (TPMT) and glutathione-S-transferases (GSTs) on the outcome ...
Editorial: Improving cancer chemotherapy through pharmacogenomics: A research topic
(Frontiers Research Foundation, 2015)
Pharmacogenetics of glucocorticoid replacement could optimize the treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency
(Faculdade de Medicina / USP, 2011-01-01)
INTRODUCTION: 21-hydroxylase deficiency is an autosomal recessive disorder that causes glucocorticoid deficiency and increased androgen production. Treatment is based on glucocorticoid replacement; however, interindividual ...
Pharmacogenetics of glucocorticoid replacement could optimize the treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency
(Faculdade de Medicina / USP, 2011)
INTRODUCTION: 21-hydroxylase deficiency is an autosomal recessive disorder that causes glucocorticoid deficiency and increased androgen production. Treatment is based on glucocorticoid replacement; however, interindividual ...