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The role of CaMKII regulation of phospholamban activity in heart disease
(Frontiers, 2014-01-27)
Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a reversible regulator of the Ca2+-ATPase (SERCA2a) activity and cardiac contractility. Dephosphorylated PLN inhibits SERCA2a and PLN ...
CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury
(Academic Press Ltd-elsevier Science Ltd, 2014-09)
Ca2+-calmodulin kinase II (CaMKII) activation is deleterious in cardiac ischemia/reperfusion (I/R). Moreover, inhibition of CaMKII-dependent phosphorylations at the sarcoplasmic reticulum (SR) prevents CaMKII-induced I/R ...
Cardiac contractility of the African sharptooth catfish, Clarias gariepinus: role of extracellular Ca2+, sarcoplasmic reticulum, and β-adrenergic stimulation
(2021-01-01)
This study investigated the dependence of contraction from extracellular Ca2+, the presence of a functional sarcoplasmic reticulum (SR), and the effects of β-adrenergic stimulation using isometric cardiac muscle preparations. ...
Disminución de la sobrecarga de información en la World Wide Web a partir de interacciones dialógicas hombre-computador
(Pontificia Universidad Católica de Valparaíso<br> Instituto de Literatura y Ciencias del Lenguaje, 2009)
El treebank del español "IPROCOLDI": componente anotado del corpus CODIMEP-CR
(2014-06-30)
This paper describes the process followed in order to create a Spanish treebank in the framework of the research project No. 745-B1-244 Interfaz para el procesamiento de corpus lingüísticos digitales – IPROCOLDI (Interface ...
Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
(SAFIS, 2010-11)
Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial ...
Disruption of Saccharomyces cerevisiae by Plantaricin 149 and investigation of its mechanism of action with biomembrane model systems
(ELSEVIER SCIENCE BV, 2009)
The action of a synthetic antimicrobial peptide analog of Plantaricin 149 (Pln149a) against Saccharomyces cerevisiae and its interaction with biomembrane model systems were investigated. Pln149a was shown to inhibit S. ...
CaMKLL regulation of phospholamban and SR Ca2 load
(Elsevier Science Inc, 2011-05)
Phospholamban (PLN) is a small phosphoprotein in the cardiac sarcoplasmic reticulum (SR). Dephosphorylated PLN tonically inhibits the SR Ca2 -ATPase (SERCA2a), and phosphorylation of PLN, at either Ser16 by PKA or Thr17 ...
Contribution of the tyr-1 in plantaricin149a to disrupt phospholipid model membranes
(MDPI AGBasel, 2013-06)
Plantaricin149a (Pln149a) is a cationic antimicrobial peptide, which was suggested to cause membrane destabilization via the carpet mechanism. The mode of action proposed to this antimicrobial peptide describes the induction ...
No evidence for an association between the-36A > C phospholamban gene polymorphism and a worse prognosis in heart failure
(BIOMED CENTRAL LTD, 2009)
Background: In Brazil, heart failure leads to approximately 25,000 deaths per year. Abnormal calcium handling is a hallmark of heart failure and changes in genes encoding for proteins involved in the re-uptake of calcium ...