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Neuroprotection in Hypoxic-Ischemic Brain Injury Targeting Glial Cells
(Bentham Science Publishers, 2017-10)
Brain injury constitutes a disabling health condition of several etiologies. One of the major causes of brain injury is hypoxia-ischemia. Until recently, pharmacological treatments were solely focused on neurons. In the ...
Neuroprotective actions of estradiol revisited
(Elsevier, 2011-12)
Results from animal experiments showing that estradiol is neuroprotective were challenged 10 years ago by findings indicating an increased risk of dementia and stroke in women over 65 years of age taking conjugated equine ...
Neurogenic neuroprotection: Future perspectives
(VERSITAWARSAW, 2013-08-02)
Neurogenic neuroprotection elicited by deep brain stimulation is emerging as a promising approach for treating patients with ischemic brain lesions. In rats, stimulation of the fastigial nucleus, but not dentate nucleus, ...
Docosahexaenoic and arachidonic acids as neuroprotective nutrients throughout the life cycle
(MDPI, 2021)
The role of docosahexaenoic acid (DHA) and arachidonic acid (AA) in neurogenesis and brain
development throughout the life cycle is fundamental. DHA and AA are long-chain polyunsaturated
fatty acids (LCPUFA) vital for ...
Neuroprotection by steroids after neurotrauma in organotypic spinal cord cultures: A key role for progesterone receptors and steroidal modulators of GABAA receptors
(Elsevier, 2013-08-31)
Progesterone is neuroprotective after spinal cord injury, however its mechanism of action remains unexplored. Here we used organotypic spinal cord slice cultures from 3 weeks-old mice to evaluate the mechanisms of ...
Neuroprotective effects of gabaergic phenols correlated with their pharmacological and antioxidant properties
(Pergamon-Elsevier Science Ltd, 2017-04-15)
Aims. Various investigations have demonstrated the protective capacity of general anesthetics as neuroprotective agents. The effects of propofol against ischemia are known to reside in its antioxidant properties and its ...
Partial neuroprotection by 17-β-estradiol in neonatal gamma-irradiated rat cerebellum
(Elsevier, 2011-02)
Acute and long-term complications can occur in patients receiving radiation therapy. It has been suggested that cytoprotection might decrease the incidence and severity of therapy-related toxicity in these patients. ...
mGlu3 receptor and astrocytes: Partners in neuroprotection
(Elsevier, 2013-03)
Astrocytes are currently studied intensively because of their now highlighted relevance as key players with neurons that modulate a wide range of central functions, from synaptic plasticity and synaptogenesis to regulation ...
Neuroprotection and sex steroid hormones: evidence of estradiol mediated protection in hypertensive encephalopathy
(Bentham Science Publishers, 2012)
Besides their effects on reproduction, estrogens exert neuroprotective effects for brain diseases. Thus, estrogens ameliorate the negative aspects of aging and age-associated diseases in the nervous system, including ...