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Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats
(Elsevier Ireland Ltd, 2018)
© 2018 Elsevier B.V. Triheptanoin, the medium-chain triglyceride of heptanoate, has been shown to be anticonvulsant and neuroprotective in several neurological disorders. In the gastrointestinal tract, triheptanoin is ...
p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing
(Wiley & Sons, 2015)
CDK5 plays an important role in neurotransmission and synaptic plasticity in the normal function of the adult brain, and dysregulation can lead to Tau hyperphosphorylation and cognitive impairment. In a previous study, we ...
Identification of potential natural neuroprotective molecules for Parkinson's disease by using chemoinformatics and molecular docking
(2020-01-01)
Parkinson’s disease is a progressive nervous system disorder characterized by motor, cognitive, sensory, psychiatric, and autonomic disturbances. While there is currently no cure for Parkinson’s Disease, medication can ...
Heteroarylnitrones as Drugs for Neurodegenerative Diseases: Synthesis, Neuroprotective Properties, and Free Radical Scavenger Properties
(American Chemical Society, 2008-09)
New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents
on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the
oxidative ...
Triheptanoin protects against status epilepticus induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration
(Wiley, 2018)
Triheptanoin, the triglyceride of heptanoate, is anaplerotic (refills deficient tricarboxylic acid cycle intermediates) via the propionyl-CoA carboxylase pathway. It has been shown to be neuroprotective and anticonvulsant ...
Docosahexaenoic acid (DHA), a fundamental fatty acid for the brain: new dietary sources
(Elsevier, 2017)
Docosahexaenoic acid (C22: 6n-3, DHA) is a long-chain polyunsaturated fatty acid of marine origin fundamental for the formation and function of the nervous system, particularly the brain and the retina of humans. It has ...
On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease
(Medknow Publications & Media Pvt, 2017)
For 50 years ago was introduced L-3,4-dihydroxyphenylalanine (L-dopa) in Parkinson's disease treatment and during this significant advances has been done but what trigger the degeneration of the nigrostriatal system remain ...
Neuroprotective Effect of a New 7,8-Dihydroxycoumarin-Based Fe2+/Cu2+ Chelator in Cell and Animal Models of Parkinson’s Disease
(American Chemical Society, 2017)
© 2016 American Chemical Society.Disturbed iron homeostasis, often coupled to mitochondrial dysfunction, plays an important role in the progression of common neurodegenerative diseases such as Parkinson’s disease (PD). ...
The Flavonoid Agathisflavone from Poincianella pyramidalis Prevents Aminochrome Neurotoxicity
(Springer, 2020)
Flavonoids have been suggested to protect dopaminergic neurons in Parkinson’s disease based on studies that used exogenous
neurotoxins. In this study, we tested the protective ability of agathisflavone in SH-SY5Y cells ...
Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration
(Blackwell Publishing Ltd, 2018)
© 2017 International Society for Neurochemistry Triheptanoin, the triglyceride of heptanoate, is anaplerotic (refills deficient tricarboxylic acid cycle intermediates) via the propionyl-CoA carboxylase pathway. It has been ...