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The Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic Paraplegias
(Frontiers Media, 2016)
The capacity of the nervous system to generate neuronal networks relies on the establishment and maintenance of synaptic contacts. Synapses are composed of functionally different presynaptic and postsynaptic compartments. ...
Unraveling the role of motoneuron autophagy in ALS
(Taylor and Francis Inc., 2018)
© 2018 Informa UK Limited, trading as Taylor & Francis Group. In recent years, the role of autophagy in the pathogenesis of most neurodegenerative diseases has transitioned into a limbo of protective or detrimental effects. ...
Botulinum neurotoxin: Evolution from poison, to research tool - Onto medicinal therapeutic and future pharmaceutical panacea
(2007)
Botulinum neurotoxin (BoNT), for more than a hundred years, has been a recognized poisonous principle in spoiled food. As its chemical structure became unraveled, and as more knowledge was gained over its mechanism of ...
Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca2+ Channels
(Nature Publishing Group, 2016)
The DLG-MAGUK subfamily of proteins plays a role on the recycling and clustering of glutamate receptors (GLUR) at the postsynaptic density. discs-large1 (dlg) is the only DLG-MAGUK gene in Drosophila and originates two ...
Dlg Is required for short-term memory and interacts with NMDAR in the drosophila brain
(MDPI, 2022)
The vertebrates’ scaffold proteins of the Dlg-MAGUK family are involved in the recruitment,
clustering, and anchoring of glutamate receptors to the postsynaptic density, particularly the NMDA
subtype glutamate-receptors ...
Casein kinase 2-dependent serine phosphory ation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction
(COLD SPRING HARBOR LAB PRESS, 2006-07-01)
The release of Agrin by motoneurons activates the muscle-specific receptor tyrosine kinase (MuSK) as the main organizer of subsynaptic specializations at the neuromuscular junction. MuSK downstream signaling is largely ...
Sugammadex en paciente neonataL
(Sociedad Colombiana de Anestesiología y ReanimaciónColombia, 2013-04-01)
Introducción:La inclusión de drogas que revierten efectivamente el bloqueo de la placa neuromuscular mejora el perfil de uso de los medicamentos que la relajan, y más aún si estos carecen de efectos adversos de importancia ...
A Perisynaptic Ménage à Trois between Dlg, DLin-7, and Metro Controls Proper Organization of Drosophila Synaptic Junctions
(2010-04-28)
Structural plasticity of synaptic junctions is a prerequisite to achieve and modulate connectivity within nervous systems, e.g., during
learning and memory formation. It demands adequate backup systems that allow remodeling ...
Dysfunctional chemosensation in myasthenia gravis : A systematic review
(2013-09)
Myasthenia gravis has traditionally been viewed as a disorder that solely affects the neuromuscular junction within the peripheral nervous system. However, there is now evidence that the cholinergic dysfunction of this ...
Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97
(COMPANY OF BIOLOGISTS LTD, 2004-04-15)
Stardust (Sdt) and Discs-Large (Dig) are membrane-associated guanylate kinases (MAGUKs) involved in the organization of supramolecular protein complexes at distinct epithelial membrane compartments in Drosophila. Loss of ...