Now showing items 1-10 of 106
Proteção miocárdica ao coração hipertrofiado: O eterno desafio
The myocardial protection allowed great advance in cardiac surgery, decreasing the mortality and making more feasible complex surgeries. Latterly, the patient population elected for cardiac procedures has been changing ...
Erythropoietin protects the systolic function of neonatal hearts against ischaemia/reperfusion injury
(Oxford Univ Press IncCaryEUA, 2013)
Cellular mechanisms against ischemia reperfusion injury induced by the use of anesthetic pharmacological agents
Ischemia–reperfusion (IR) cycle in the myocardium is associated with activation of an injurious cascade, thus leading to new myocardial challenges, which account for up to 50% of infarct size. Some evidence implicates ...
Calpain translocation and activation as pharmacological targets during myocardial ischemia/reperfusion
Calpains contribute to reperfusion-induced myocardial cell death. However, it remains controversial whether its activation occurs during ischemia or reperfusion. We investigated the regulation and time-course of calpain ...
Challenges of Translational Science
(Arquivos Brasileiros Cardiologia, 2017-05-01)
The electrogenic cardiac sodium bicarbonate co-transporter (NBCe1) contributes to the reperfusion injury
(Elsevier Science Inc, 2014-07)
Background: Although the participation of the electrogenic sodium/bicarbonate cotransporter (NBCe1) in the recovery from an intracellular acid load is recognized, its role in ischemia–reperfusion is still unclear. Methods ...
Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart
Pharmacological preconditioning limits myocardial infarct size after ischemia/reperfusion. Dexmedetomidine is an alpha(2)-adrenergic receptor agonist used in anesthesia that may have cardioprotective properties against ...