Search
Now showing items 1-10 of 28
Mitochondria, myocardial remodeling, and cardiovascular disease
(2012)
The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes
(Elsevier Inc., 2014)
© 2014 Elsevier Inc. All rights reserved. Metabolic and cardiovascular disease patients have increased plasma levels of lipids and, specifically, of palmitate, which can be toxic for several tissues. Trimetazidine (TMZ), ...
Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake
(2014)
Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
Subcellular structure of prenatal human ovary: Mitochondrial distribution during meiotic prophase
(1990)
The dynamics of mitochondrial population during the first meiotic prophase in the fetal human ovary was studied in sequential stages of development, from week 13 to week 23 of intrauterine life; the study was performed by ...
Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway
(Company of Biologists Ltd, 2014)
Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism. Mitochondria are crucial organelles for the production of ATP, and their morphology and function are regulated by the dynamic processes ...
Mitochondrial dynamics: A potential new therapeutic target for heart failure Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca
(2011)
Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. ...
Mitochondrial dynamics, mitophagy and cardiovascular disease
(WILEY-BLACKWELL, 2016)
Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or myocardial injury, and allows the heart to meet an increased demand for oxygen. Although initially beneficial, hypertrophy can ...
Adaptive responses of mitochondria to mild copper deprivation involve changes in morphology, OXPHOS remodeling and bioenergetics
(Wiley-Liss Inc., 2014)
Copper is an essential cofactor of complex IV of the electron transfer chain, and it is directly involved in the generation of mitochondrial membrane potential. Its deficiency induces the formation of ROS, large mitochondria ...
The antioxidant N-acetylcysteine prevents the mitochondrial fragmentation induced by soluble amyloid-β peptide oligomers
(2012)
Background: Soluble amyloid-β peptide oligomers (AβOs), which are centrally involved in the pathogenesis of Alzheimer's disease, trigger Ca 2+ influx through N-methyl-D-aspartate receptors and stimulate reactive oxygen ...
Description of a new Eupsophus species (Amphibia, Leptodactylidae) from the remnants of Maulino forest, central Chile
(2005)
The description of a new species of Eupsophus, from Los Queules National Reserve (35° 59' S, 72° 41'W) adds a new endemic taxon to the fauna of telmatobines (Amphibia, Leptodactylidae) of Chile, and extends the geographical ...