Now showing items 1-10 of 74
Mitochondrial fission and autophagy in the normal and diseased heart
Sustained hypertension promotes structural, functional and metabolic remodeling of cardiomyocyte mitochondria. As long-lived, postmitotic cells, cardiomyocytes turn over mitochondria continuously to compensate for changes ...
Ceramide-induced BOK promotes mitochondrial fission in preeclampsia
Mitochondria are in a constant balance of fusing and dividing in response to cellular cues. Fusion creates healthy mitochondria, whereas fission results in removal of non-functional organelles. Changes in mitochondrial ...
Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway
(Company of Biologists Ltd, 2014)
Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism. Mitochondria are crucial organelles for the production of ATP, and their morphology and function are regulated by the dynamic processes ...
Mitochondria, myocardial remodeling, and cardiovascular disease
The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction
BACKGROUND: Ischemia and reperfusion (IR) injury remains a major cause of morbidity and mortality and multiple molecular and cellular pathways have been implicated in this injury. We determined whether acute inhibition ...
MITOCHONDRIAL FISSION IS REQUIRED FOR CARDIOMYOCYTE HYPERTROPHY MEDIATED BY A CA2+-CALCINEURIN SIGNALING PATHWAY
(CAMBRIDGE UNIVERSITY PRESS, 2014)
MITOCHONDRIAL FISSION AND AUTOPHAGY IN THE NORMAL AND DISEASED HEART