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Efeito do knockout da Mitofusina 1 sobre a fertilidade de oócitos murinos
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEvCâmpus São Carlos, 2018-08-31)
Fertility is directly related to oocyte developmental competence. In this context, oocyte mitochondria play a crucial role and have become an important target in assisted reproduction therapies. However, the molecular ...
Characterizing the phenotypic manifestations of MFN2 R104W mutation in Charcot-Marie-Tooth type 2
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Mutations of the mitofusin 2 (MFN2) gene have been reported to be the most common cause of the axonal form of Charcot Marie Tooth disease (CMT). The aim of this study was to describe a de novo MFN2 p.R104W mutation and ...
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway
(Nature Publishing Group, 2016-08)
Mitochondrial dysfunction and accumulation of damaged mitochondria are considered major contributors to aging. However, the molecular mechanisms responsible for these mitochondrial alterations remain unknown. Here, we ...
Efeito do nocaute da mitofusina 2 sobre a mitocôndria, o retículo endoplasmático e a mitofagia em oócitos murinos
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEvCâmpus São Carlos, 2018-08-24)
Mitofusins 1 (MFN1) and 2 (MFN2) are transmembrane GTPases present in the outer mitochondrial membrane and involved in the regulation of mitochondrial fusion. Since MFN2 is also present in the membrane of the endoplasmic ...
Effects of High Iron and Glucose Concentrations over the Relative Expression of Bcl2, Bax, and Mfn2 in MIN6 Cells
(Springer Science+Business Media, 2013)
Type 2 diabetes is characterized by hyperglycemia
and oxidative stress. Hyperglycemia is linked to mitochondrial
dysfunction and reduced β-cell mass due to the
reduced expression of genes such as Mfn2 as well as ...
Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up-regulation of mfn2 and opa1 in erythropoietic cells
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2013)
Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up - regulation of mfn2 and opa1 in erythropoietic cells
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2013)
Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up - regulation of mfn2 and opa1 in erythropoietic cells
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2013)
Efecto cardioprotector de N-Acetilcisteína en el daño producido por isquemia, sobre el contenido de Mitofusina 2, en corazón aislado de rata
(Universidad de Chile, 2016)
El infarto agudo de miocardio es la principal causa de muerte por enfermedad isquémica coronaria en Chile. Durante isquemia predomina el metabolismo anaeróbico, disminuye la síntesis de ATP y se generan especies reactivas ...