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Longitudinal analysis of metalloproteinases, tissue inhibitors of metalloproteinases and clinical parameters in gingival crevicular fluid from periodontitis-affected patients
(2005)
Background: The aim of this work was to improve the assessment of the
periodontal disease status through measurements of extracellular matrix
metalloproteinases (MMPs) and their tissular inhibitors (TIMPs) in the ...
Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts
(Elsevier, 2015)
Periodontitis is a highly prevalent infectious disease characterized by the progressive inflammatory
destruction of tooth-supporting structures, leading to tooth loss. The underling molecular mechanisms
of the disease ...
Tumor necrosis factor-astimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts
(Blackwell Munksgaard, 2007-12-11)
Membrane type 1-matrix metalloproteinase (MT1-
MMP) is a collagenolytic enzyme involved in connective tissue remodeling. In
periodontal tissues, either cytokines or growth factors regulate the production of
proteolytic ...
Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi
(2012)
Background: Chagas' disease is caused by the haemophlagelated protozoan Trypanosoma cruzi (T. cruzi). During congenital transmission the parasite breaks down the placental barrier. In the present study we analyzed the ...
Gelatinolytic activity in gingival crevicular fluid from teeth with periapical lesions
(MOSBY-ELSEVIER, 2008-06)
Objective. Many matrix metalloproteinases ( MMPs) have been associated with periodontal tissue destruction during chronic and apical periodontitis. The aim of this study was to determine gelatinolytic activity in gingival ...
Tumor necrosis factor-α-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts
(2009)
Background and Objectives: Membrane type 1-matrix metalloproteinase (MT1-MMP) is a collagenolytic enzyme involved in connective tissue remodeling. In periodontal tissues, either cytokines or growth factors regulate the ...
Expression of Toll-like receptors 2 and 4 and its association with matrix metalloproteinases in symptomatic and asymptomatic apical periodontitis
(Springer Verlag, 2019)
To determine Toll-like receptors (TLR)2 and TLR4 expression levels and associate them with matrix metalloproteinases (MMPs) in asymptomatic apical periodontitis (AAP), symptomatic apical periodontitis (SAP), and healthy ...
Matrix metalloproteinase-8 regulates transforming growth factor-β1 levels in mouse tongue wounds and fibroblasts in vitro
(Academic Press Inc., 2014)
© 2014 Elsevier Inc. Matrix metalloproteinase-8 (MMP-8)-deficient mice (Mmp8-/-) exhibit delayed dermal wound healing, but also partly contradicting results have been reported. Using the Mmp8-/- mice we investigated the ...
CYCLIC AMP INHIBITS TGF
(Wiley-Liss, Inc., 2003-07-04)
Mouse-transformed keratinocytes cultured in the presence
of transforming growth factor 1 (TGF- 1) acquire an array
of morphologic and functional properties that give rise to a
migratory phenotype that expresses mesenchymal ...
Early pregnancy levels of gingival crevicular fluid matrix metalloproteinases-8 and −9 are associated with the severity of periodontitis and the development of gestational diabetes mellitus
(Wiley, 2020)
Background Gestational diabetes mellitus (GDM) is increasing worldwide and women with a history of GDM are at risk of developing type 2 diabetes which is a risk factor for periodontitis. Aim To explore the association ...