Now showing items 1-10 of 307
Differential effects of TR ligands on hormone dissociation rates: Evidence for multiple ligand entry/exit pathways
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Some nuclear receptor (NR) ligands promote dissociation of radiolabeled bound hormone from the buried ligand binding cavity (LBC) more rapidly than excess unlabeled hormone itself This result was interpreted to mean that ...
Participation of the Protein Ligands in the Folding of Cytochrome c
Absorption spectral, circular dichroic spectral, and viscosity measurements indicate that the compact low-spin conformation characteristic of native cytochrome c is quantitatively recovered from its extended high-spin ...
Stabilization of the Globular Structure of Ferricytochrome c by Chloride in Acidic Solvents
Increasing concentrations of chloride were found to increase the resolution between two visible absorbance spectral transitions associated with acidification of ferricytochrome c. Analysis of a variety of spectral and ...
Monitoring Protein-protein, Protein-dna, And Protein-ligand Interactions In Silico And In Vitro
(BENTHAM SCIENCE PUBL LTDSHARJAH, 2015)
Fasting and post-glucose ghrelin levels in SGA infants: Relationships with size and weight gain at one year of age
Wide ranges in postnatal weight gain are seen in infants born small for gestational age (SGA); most show some catch-up growth and this may be driven by increased appetite. Ghrelin, the natural ligand of the GH secretagogue ...
Influence of ligands on the aggregation of the normal and mutant forms of phosphofructokinase 2 of Escherichia coli
The aggregation states of Escherichia coli phosphofructokinase 2 (Pfk-2) and of a mutant enzyme (Pfk-2*) altered in the inhibitory allosteric site for MgATP were measured in the presence and in the absence of substrates ...
Improving binding affinity prediction by using a rule-based model with physical-chemical and structural descriptors of the nano-environment for protein-ligand interactions.
(In: CONGRESS OF THE INTERNATIONAL UNION FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 23.; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 44., 2015, Foz do Iguaçu. Biochemistry for a better world: abstracts book. [Foz do Iguaçu]: SBBq, 2015., 2015)
Ligand-dependent structural changes and limited proteolysis of Escherichia coli phosphofructokinase-2
Binding of MgATPto the allosteric site of phosphofructokinase-2 promotes a dimer to tetramer conversion. In the presence of Fru-6-Pthe enzyme remains as a dimer. Limited proteolysis in the presence of MgATPcompletely ...
Ligand-induced conformational transitions in Escherichia coli phosphofructokinase 2: Evidence for an allosteric site for MgATP2-
The binding of ligands to phosphofructokinase 2 (Pfk-2) from Escherichia coli induces changes in the fluorescence emission properties of its single tryptophan residue, Trp88, suggesting that upon binding the protein ...