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Protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats
Maternal malnutrition was shown to affect early growth and leads to permanent alterations in insulin secretion and sensitivity of offspring. In addition, epidemiological studies showed an association between low birth ...
Análogos de insulina: en búsqueda del reemplazo fisiológico
(Sociedad Médica de Santiago, 2006)
Effects of fluoride intake on insulin sensitivity and insulin signal transduction
(Int Soc Fluoride Research, 2008-10-01)
Forty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered ...
Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients
(Associação Brasileira de Divulgação Científica (ABRADIC), 2003-03-01)
To identify early metabolic abnormalities in type 2 diabetes mellitus, we measured insulin secretion, sensitivity to insulin, and hepatic insulin extraction in 48 healthy normal glucose-tolerant Brazilians, first-degree ...
Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets
(Elsevier B.V., 1995-12-27)
The presence of tyrosine-phosphorylated proteins was studied in cultured rat pancreatic islets, Immunoblotting performed with total extracts of islets cultured in the presence of 1.8 or 5.6 mM glucose revealed at least ...
Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride
(Int Soc Fluoride Research, 2010-01-01)
With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated ...
Insulin signaling proteins in pancreatic islets of insulin-resistant rats induced by glucocorticoid
(Soc Biolgia Chile, 2011-01-01)
Chronic administration of glucocorticoids induces insulin resistance that is compensated by an increase in beta-cell function and mass. Since insulin signaling is involved in the control of beta-cell function and mass, we ...