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The effects of immunomodulation by macrophage subsets on osteogenesis in vitro
(BioMed Central, 2016)
Background: Bone formation and remodeling are influenced by the inflammatory state of the local microenvironment. In this regard, macrophages are postulated to play a crucial role in modulating osteogenesis. However, the ...
Vaccines against components of the renin-angiotensin system
(Springer, 2020)
Even though effective drugs for treating hypertension are available, a great percentage of patients have inadequate control of their blood pressure. Unwanted side effects and inappropriate oral drug adherence are important ...
Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents
(2006)
The chemical structure of phenothiazine provides a most valuable molecular template for the development of agents able to interact with a wide variety of biological processes. Synthetic phenothiazines (with aliphatic, ...
Eosinophils Control Liver Damage by Modulating Immune Responses AgainstFasciola hepatica
(Frontiers Media, 2020)
Eosinophils are granulocytes that participate in the defense against helminth parasites and in hypersensitivity reactions. More recently, eosinophils were shown to have other immunomodulatory functions, such as tissue ...
In vitro Treatment of a Murine Mammary Adenocarcinoma Cell Line with Recombinant Trypanosoma cruzi Calreticulin Promotes Immunogenicity and Phagocytosis
(Elsevier, 2020)
American Trypanosomiasis, a parasitic disease produced by Trypanosoma cruzi (T. cruzi), endemic in Latin America, infects about 6 million people. During the chronic stage of the infection, approximately 30% of infected ...
Immunomodulatory and immunogenic properties of mesenchymal stem cells derived from bovine fetal bone marrow and adipose tissue
(Elsevier B.V., 2019)
Little information is currently available on therapeutic features of bovine mesenchymal stem cells (MSCs), despite the development of large animal experimental models including cattle may open alternative strategies for ...
TonEBP suppresses IL-10-mediated immunomodulation
(Nature, 2016)
TonEBP is a key transcriptional activator of M1 phenotype in macrophage, and its high expression is associated with many inflammatory diseases. During the progression of the inflammatory responses, the M1 to M2 phenotypic ...
Pravastatin immunomodulates IL-6 and C-reactive protein, but not IL-1 and TNF-α, in cardio-pulmonary bypass
(2008)
Background. While statins are increasingly used in cardiopulmonary bypass (CPB), the anti inflammatory effects of individual statins, within the context of various treatment regimes, need further examination. The present ...
Immunomodulation and antioxidant activities aspossible trypanocidal and cardioprotectivemechanisms of major terpenes from lippia albaessential oils in an experimental model of chronicchagas disease
(Suiza, 2021-11-22)
In the late phase of Trypanosoma cruzi infection, parasite persistence and an exaggerated immune response accompanied by oxidative stress play a crucial role in the genesis of Chronic Chagasic Cardiomyopathy (CCC). Current ...