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Marker-assisted selection and genomic selection
(2017-06-10)
Breeding techniques and molecular tools, i.e., biotechnology, have increased crop yield over the last century. Marker-assisted selection and, more recently, genome-wide association studies and genomic selection have been ...
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
(Springer Nature, 2018)
To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A ...
Genomic signatures of pre-resistance in Mycobacterium tuberculosis.
(Springer Nature, 2021)
Recent advances in bacterial whole-genome sequencing have resulted in a comprehensive catalog of antibiotic resistance genomic signatures in Mycobacterium tuberculosis. With a view to pre-empt the emergence of resistance, ...
Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans
(Public Library of Science, 2018)
Hair plays an important role in primates and is clearly subject to adaptive selection. While humans have lost most facial hair, eyebrows are a notable exception. Eyebrow thickness is heritable and widely believed to be ...
A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features
(Springer Nature, 2016)
We report a genome-wide association scan in over 6,000 Latin Americans for features of scalp hair (shape, colour, greying, balding) and facial hair (beard thickness, monobrow, eyebrow thickness). We found 18 signals of ...