Now showing items 1-10 of 212
Isoproterenol induces primary loss of dystrophin in rat hearts: correlation with myocardial injury
The mechanism of isoproterenol-induced myocardial damage is unknown, but a mismatch of oxygen supply vs. demand following coronary hypotension and myocardial hyperactivity is the best explanation for the complex morphological ...
Dystrophin proteolysis: a potential target for MMP-2 and its prevention by ischemic preconditioning
(American Physiological Society, 2014-07)
Dystrophin is responsible for the mechanical stabilization of the sarcolemma, and it has been shown that it is one of the most sensitive proteins to ischemic injury. However, the enzyme responsible for this proteolysis is ...
Disruption of sarcolemmal dystrophin and beta-dystroglycan may be a potential mechanism for myocardial dysfunction in severe sepsis
(NATURE PUBLISHING GROUP, 2010)
Evidence from our laboratory has shown alterations in myocardial structure in severe sepsis/septic shock. The morphological alterations are heralded by sarcolemmal damage, characterized by increased plasma membrane ...
ALTERED GENE EXPRESSION PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY
Duchenne muscular dystrophy (DMD) is caused by the absence of functional dystrophin (Blake et al. 2002). Dystrophin is a cytoskeleton protein normally expressed in the inner face of the plasma membrane (Ahn and Kunkel ...
Early dystrophin disruption in the pathogenesis of experimental chronic Chagas cardiomyopathy
(ELSEVIER SCIENCE BVAMSTERDAM, 2013-08-02)
Chronic Chagas cardiomyopathy evolves over a long period of time after initial infection by Trypanosoma cruzi. Similarly, a cardiomyopathy appears later in life in muscular dystrophies. This study tested the hypothesis ...