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Paul Ehrlich : From magic bullets to chemotherapy.
(2012-01-10)
Paul Ehrlich is one of the most notable figures in the world of science. Considered by many as the father of chemotherapy,
he was awarded the Nobel Prize in Physiology and Medicine in 1908 for his contributions to immunology. ...
Total neoadjuvant chemotherapy with FLOT scheme in resectable adenocarcinoma of the gastro-oesophageal junction or gastric adenocarcinoma: impact on pathological complete response and safety
(Cancer Intelligence, 2020)
Background: Gastric cancer is the fifth cause of cancer incidence worldwide. Multidisciplinary
approaches that improve the survival are needed. Perioperative chemotherapies
show improvement in pathological complete ...
Role of radiotherapy in patients with early-stage diffuse large B-cell lymphoma of Waldeyer's ring in remission after anthracycline-containing chemotherapy
(2013)
Consolidation radiotherapy (cRT) in patients with stage I/II diffuse large B-cell lymphoma of the Waldeyer's ring (WR-DLBCL) in complete remission (CR) after induction chemotherapy (CHT) is often associated with relevant ...
Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial
(Amer Medical Assoc, 2020)
IMPORTANCE Safe and effective therapies for untreated, advanced gastric/gastroesophageal junction (G/GEJ) cancer remain an unmet need.
OBJECTIVE To evaluate the antitumor activity of pembrolizumab, pembrolizumab plus ...
Quality of life and physical function in adults treated with intensive chemotherapy for acute myeloid leukemia improve over time independent of age
(Elsevier, 2015)
Objectives: Intensive chemotherapy (IC) is the primary treatment of acute myeloid leukemia (AML) but is associated with significant toxicity, particularly in older adults. We characterized the impact of AML and its treatment ...
Studies on quinones. Part 36. Synthesis and trypanocidal activity of 2-alkoxycarbonylbenzo[b]thiophene-4,7-quinones
(FREUND PUBLISHING HOUSE LTD, 2002)
A series of 2-alkoxycarbonylbenzo[b]thiophene-4,7-quinones (11-15), prepared from the corresponding acid 5, were tested in vitro against trypomastigote form of Trypanosome cruzi. The influence of the lypophilia and oxidant ...
Metformin and cancer: Between the bioenergetic disturbances and the antifolate activity
(Elsevier, 2015)
For decades, metformin has been the first-line drug for the treatment of type II diabetes mellitus, and it thus is the most widely prescribed antihyperglycemic drug. Retrospective studies associate the use of metformin ...