Now showing items 1-10 of 46
Organogenesis from leaf and internode explants of Ophiorrhiza prostrata, an anticancer drug (camptothecin) producing plant
(Pontificia Universidad Católica de Valparaíso, 2007)
Self-aggregates of 3,6-O,O’-dimyristoylchitosan derivative are effective in enhancing the solubility and intestinal permeability of camptothecin
The aim of this work was to investigate the potential of a new 3,6-O,O’-dimyristoyl derivative amphiphilic chitosan (DMCh), in improving the solubility of camptothecin (CPT), a hydrophobic anticancer drug, and its potential ...
The effect of siRNA-Egr-1 and camptothecin on growth and chemosensitivity of breast cancer cell lines
We have examined the effects of a siRNA targeting the Egr-1, alone or in combination with the breast cancer therapeutic camptothecin (Cpt), in suppressing breast cancer cell survival and anchorage-independent growth in the ...
THE EFFECT OF SIRNA-EGR-1 AND CAMPTOTHECIN ON GROWTH AND CHEMOSENSITIVITY OF BREAST CANCER CELL LINES
(SPANDIDOS PUBL LTD, 2010)
Xyloglucan nano-aggregates: Physico-chemical characterisation in buffer solution and potential application as a carrier for camptothecin, an anti-cancer drug
(ELSEVIER SCI LTD, 2010)
In this work, native xyloglucan was extracted from Tamarindus indica seeds (XGT), and its properties in phosphate buffer solution (PBS) were evaluated in comparison with a commercial tamarind kernel powder (TKP). The ...
Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE
(Pergamon-Elsevier Science Ltd, 2017-12)
The transcriptional regulator FUSE Binding Protein 1 (FUBP1) is overexpressed in more than 80% of all human hepatocellular carcinomas (HCCs) and other solid tumor entities including prostate and colorectal carcinoma. FUBP1 ...
Topoisomerase I inhibitor, camptothecin, induces apoptogenic signaling in human embryonic stem cells
Embryonic stem cells (ESCs) need to maintain their genomic integrity in response to DNA damage to safeguard the integrity of the organism. DNA double strand breaks (DSBs) are one of the most lethal forms of DNA damage and, ...
Antiproliferative activity, isolation and identification of active compound from Gaylussacia brasiliensis
(Soc Brasileira FarmacognosiaJoao PessoaBrasil, 2011)