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Regulatory mechanisms of cAMP levels as a multiple target for antiplatelet activity and less bleeding risk
(PERGAMON-ELSEVIER SCIENCE LTD, 2014)
Antiplatelet and Antithrombotic Activities of Non-Steroidal Anti-Inflammatory Drugs Containing an N-Acyl Hydrazone Subunit
(Mdpi Ag, 2014-02-01)
Nonsteroidal anti-inflammatory drugs (NSAIDs) 1-5 containing an N-acyl hydrazone subunit were prepared and their antiplatelet and antithrombotic activities assessed in vitro and in vivo. Compounds 1-5 inhibited the platelet ...
Synthesis and preliminary evaluation of N-oxide derivatives for the prevention of atherothrombotic events
(Molecules, 2015)
Thrombosis is the main outcome of many cardiovascular diseases. Current treatments to prevent thrombotic events involve the long-term use of antiplatelet drugs. However, this therapy has several limitations, thereby ...
Risk of Early Bleeding with Dual Antiplatelet Therapy in Acute Stroke and Transient Ischemic Attack Regardless of NIHSS Admission.
(2021-05-01)
Background: Dual antiplatelet therapy (DAT) is a therapeutic option for patients with minor ischemic stroke (IS) or transient ischemic attack (TIA). No study has evaluated the incidence of early bleeding in patients with ...
Exploration of the Antiplatelet Activity Profile of Betulinic Acid on Human Platelets
(AMER CHEMICAL SOCWASHINGTON, 2012)
Betulinic acid, a natural pentacyclic triterpene acid, presents a diverse mode of biological actions including antiretroviral, antibacterial, antimalarial, and anti-inflammatory activities. The potency of betulinic acid ...
Molecular and functional characterization of a new non-hemorrhagic metalloprotease from Bothrops jararacussu snake venom with antiplatelet activity
(Elsevier B.V., 2007-12-01)
BjussuMP-II is an acidic low molecular weight metalloprotease (Mr similar to 24,000 and pI similar to 6.5), isolated from Bothrops jararacussu snake venom. The chromatographic profile in RP-HPLC and its N-terminal sequence ...
Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables
(LIPPINCOTT WILLIAMS & WILKINS, 2012)