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AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins
(Nature Publishing Group, 2017-03)
The purpose of this study was to elucidate the mechanisms associated with the specific effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the abundance of specific AKT isoforms in IBH-6 and T47D ...
Modulation of the Akt pathway reveals a novel link with PERK/eIF2alpha, which is relevant during hypoxia
(Public Library Science, 2013-07-29)
The unfolded protein response (UPR) and the Akt signaling pathway share several regulatory functions and have the capacity to determine cell outcome under specific conditions. However, both pathways have largely been studied ...
Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition
(Elsevier, 2015)
© 2015 Elsevier B.V. Connexin hemichannels are regulated under physiological and pathological conditions. Metabolic inhibition, a model of ischemia, promotes surface hemichannel activation associated, in part, with increased ...
AKT and AMPK Activation after High-Fat and High-Glucose In Vitro Treatment of Prostate Epithelial Cells
(Georg Thieme Verlag Kg, 2014-06-01)
Considering the increasing consumption of saturated fat and glucose in diets worldwide and its possible association to carcinogenesis, this investigation analysed the proliferation profile of nonmalignant human prostate ...
AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival
(Nature Publishing Group, 2016-10)
Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (PSC) that can differentiate into a wide range of specialized cells. Basic fibroblast growth factor is essential for PSC survival, ...
Akt/PKB: one kinase, many modifications
(Portland Press, 2015-06)
Akt/PKB, a serine/threonine kinase member of the AGC family of proteins, is involved in the regulation of a plethora of cellular processes triggered by a wide diversity of extracellular signals and is thus considered a key ...
INFLUÊNCIA DE DIFERENTES PROTOCOLOS DE TREINAMENTO FÍSICO SOBRE A FOSFORILAÇÃO DA PROTEÍNA AKT EM MÚSCULO ESQUELÉTICO E SENSIBILIDADE À INSULINA DE RATOS OBESOS
(Universidade Estadual de Maringá, 2015-03-01)
ABSTRACTInvestigate the effects of different protocols of physical training (PT) on insulin sensibility (IS) and Akt phosphorylation (p-Akt) in skeletal muscle of obese rats. Animals were distributed in four groups according ...
Adiponectin and Serine/Threonine Kinase Akt Modulation by Triiodothyronine and/or LY294002 in 3T3-L1 Adipocytes
(2019-02-01)
Adipose tissue (AT), an endocrine organ that modulates several physiological functions by synthesizing and releasing adipokines such as adiponectin, is a metabolic target of triiodothyronine (T3). T3 and adiponectin play ...
Angiotensin-(1-7) stimulates the phosphorylation of Akt in rat extracardiac tissues in vivo via receptor Mas
(Elsevier Science, 2010-04)
The in vivo effect of angiotensin (ANG)-(1-7) on the activation of insulin signaling transduction in rat extracardiac tissues is unknown. Thus, in the present study, we evaluated the ability of ANG-(1-7) to stimulate the ...
Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junín virus infection in Vero cells
(Springer Wien, 2014-12)
In previous work, we demonstrated that the arenavirus Junín virus (JUNV) is able to activate Akt by means of the phosphatidylinositol-3-kinase (PI3K) survival pathway during virus entry. This work extends our study, ...