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Vitreous pharmacokinetics and electroretinographic findings after intravitreal injection of acyclovir in rabbits
(HOSPITAL CLINICAS, UNIV SAO PAULOSAO PAULO, 2012)
OBJECTIVES: Acute retinal necrosis is a rapidly progressive and devastating viral retinitis caused by the herpesvirus family. Systemic acyclovir is the treatment of choice; however, the progression of retinal lesions ceases ...
DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR DEYERMINATION OF ACYCLOVIR IN POLYMERIC NANOPARTICLES
(SOC BRASILEIRA QUIMICASAO PAULO, 2012)
A derivative spectrophotometric method was validated for quzintification of acyclovir in poly (n-butylcyanoacrylate) (PBCA) nanoparticles. Specificity, linearity. precision, accuracy, recovery. detection (LOD) and ...
Derivative spectrophotometric method for determination of acyclovir in polymeric nanoparticles
(Sociedade Brasileira de Química, 2012)
A derivative spectrophotometric method was validated for quantification of acyclovir in poly (n-butylcyanoacrylate) (PBCA) nanoparticles. Specificity, linearity, precision, accuracy, recovery, detection (LOD) and quantification ...
Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir
(Elsevier B.V., 2003-08-29)
In human, purine nucleoside phosphorylase (HsPNP) is responsible for degradation of deoxyguanosine and genetic deficiency of this enzyme leads to profound T-cell mediated immunosuppression. PNP is therefore a target for ...
Prolonged treatment with acyclovir in recurrent genital herpes. Clinical, virological, and immunological response Tratamiento prolongado con acyclovir en herpes genital recurrente. Respuesta clínica, virológica e inmunológica.
(1991)
The effect of a prolonged course of oral acyclovir was evaluated in 55 pts with recurrent genital herpes (36 men and 19 women). The pts were voluntarily enrolled after an acute episode, with tissue culture viral isolation. ...
Acyclovir: Voltammetric behaviour and analytical application to pharmaceutical forms
(1996)
The electrochemical oxidation of acyclovir at different pH and concentrations using both differential pulse and cyclic voltammetry was studied. Acyclovir exhibits one differential pulse voltammetric peak at the glassy ...
Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1
(Elsevier Science, 2015-10)
The conventional therapy for the management of Herpes Simplex Virus Type 1 (HSV-1) infections mainly comprises acyclovir (ACV) and other nucleoside analogues. A common outcome of this treatment is the emergence of resistant ...