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Di erences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT2A and 5-HT2C receptors
(Nature Publishing Group, 2002-04-04)
1 The pharmacological pro®le of a series of (+)-2,5-dimethoxy-4-(X)-phenylisopropylamines
(X=I, Br, NO2, CH3, or H) and corresponding phenylethylamines, was determined in Xenopus laevis
oocytes injected with cRNA coding ...
Characterization of the feeding behavior induced by agonists 5-HT1A, 5-HT1B, 5-HT2A and 5-HT2CCaracterización de la conducta alimentaria inducida por agonista s 5-ht1a, 5-ht1b, 5-ht2a y 5-ht2c
(Sociedad Mexicana de Análisis de la Conducta / Mexican Society of Behavior Analysis, 2009)
The interplay between 5-HT2C and 5-HT3A receptors in the dorsal periaqueductal gray mediates anxiety-like behavior in mice
(2022-01-24)
The monoamine neurotransmitter serotonin (5-HT) modulates anxiety by its activity on 5-HT2C receptors (5-HT2CR) expressed in the dorsal periaqueductal gray (dPAG). Here, we investigated the presence of 5-HT3A receptors ...
5-HT2 and 5-HT3 receptors in the lateral parabrachial nucleus mediate opposite effects on sodium intake
(Elsevier B.V., 2007-06-08)
The present study investigated the role of several 5-HT receptor subtypes in the lateral parabrachial nucleus (LPBN) in the control of sodium appetite (i.e. NaCl consumption). Male Holtzman rats had cannulas implanted ...
Activation of 5-HT2C (but not 5-HT1A) receptors in the amygdala enhances fear-induced antinociception: Blockade with local 5-HT2C antagonist or systemic fluoxetine
(2018-06-01)
It is well-known that the exposure of rodents to threatening environments [e.g., the open arm of the elevated-plus maze (EPM)] elicits pain inhibition. Systemic and/or intracerebral [e.g., periaqueductal gray matter, ...
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT 2A receptor antagonists in Xenopus laevis oocytes
(2004)
1 We recently described that several 2-(2,5-dimethoxy-4-substituted phenyl)ethylamines (PEAs), including 4-I = 2C-I, 4-Br = 2C-B, and 4-CH 3 = 2C-D analogs, are partial agonists at 5-HT 2C receptors, and show low or even ...
5-HT(1A/1B), 5-HT(6), and 5-HT(7) serotonergic receptors recruitment in tonic-clonic seizure-induced antinociception: Role of dorsal raphe nucleus
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009)
Pharmacological studies have been focused on the involvement of different neural pathways in the organization of antinociception that follows tonic-clonic seizures, including 5-hydroxytryptamine (5-HT)-, norepinephrine-, ...
Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice
(2020-03-11)
Growing evidence suggests an important role of fluoxetine with serotonin 5-HT1A and 5-HT2C receptors in the modulation of emotion and nociception in brain areas such as the amygdala and periaqueductal gray (PAG). Acute ...
Blockade of 5-HT2 receptors in the periaqueductal grey matter (PAG) abolishes the anxiolytic-like effect of 5-HT1A receptor antagonism in the median raphe nucleus in mice
(Elsevier B.V., 2011-12-01)
Several lines of evidence support the involvement of serotonergic (5-HT) neurons of the median raphe nucleus (MRN) in anxiety-like behaviour. In this context, it is known that blockade of 5-HT1A somatodendritic autoreceptors ...