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Molecular modeling of the α9α10 nicotinic acetylcholine receptor subtype
(2009)
This study reports the comparative molecular modeling, docking and dynamic simulations of human α9α10 nicotinic acetylcholine receptors complexed with acetylcholine, nicotine and α-conotoxin RgIA, using as templates the ...
Mecamylamine-precipitated nicotine withdrawal syndrome and its prevention with baclofen: An autoradiographic study of α4β2 nicotinic acetylcholine receptors in mice
(Elsevier, 2013-07-01)
A previous study from our laboratory showed that baclofen (BAC, GABAB receptor agonist) was able to prevent the behavioral expression of nicotine (NIC) withdrawal syndrome. To further investigate the mechanisms underlying ...
Functional expression of the α7 and α4-containing nicotinic acetylcholine receptors on the neonatal rat carotid body
(2012)
The carotid bodies (CBs) are chemosensory organs that respond to hypoxemia with transmitter neurosecretion, leading to a respiratory reflex response. It has been proposed that acetylcholine is a key regulator of transmitter ...
Activity of cytisine and its brominated isosteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors
(2001)
Effects of cytisine (cy), 3-bromocytisine (3-Br-cy), 5-bromocytisine (5-Br-cy) and 3,5-dibromocytisine (3,5-diBr-cy) on human (h) α7-, α4β2- and α4β4 nicotinic acetylcholine (nACh) receptors, expressed in Xenopus oocytes ...
Difference in perseverative errors during a visual attention task with auditory distractors in alpha-9 nicotinic receptor subunit wild type and knock-out mice
(Frontiers Media S.A., 2017)
© 2017 Jorratt, Delano, Delgado, Dagnino-Subiabre and Terreros. The auditory efferent system is a neural network that originates in the auditory cortex and projects to the cochlear receptor through olivocochlear (OC) ...
Molecular function of α7 nicotinic receptors as drug targets
(Wiley Blackwell Publishing, Inc, 2018-05-13)
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels involved in many physiological and pathological processes. In vertebrates, there are seventeen different nAChR subunits that combine to ...
Neonicotinic analogues: Selective antagonists for α4β2 nicotinic acetylcholine receptors
(2013)
Nicotine is an agonist of nicotinic acetylcholine receptors (nAChRs) that has been extensively used as a template for the synthesis of α4β2-preferring nAChRs. Here, we used the N-methyl-pyrrolidine moiety of nicotine to ...
Methylpiperidinium iodides as novel antagonists for α7 nicotinic acetylcholine receptors
(Frontiers Media S.A., 2018)
© 2018 López, García-Colunga, Pérez and Fierro. The α7 nicotinic acetylcholine receptor (nAChR) is expressed in neuronal and non-neuronal cells and is involved in several physiopathological processes, and is thus an important ...
α7-type acetylcholine receptor localization and its modulation by nicotine and cholesterol in vascular endothelial cells
(Wiley, 2011-06)
The neuronal-type 7 nicotinic acetylcholine receptor (7AChR) is also found in various non-neural tissues, including vascular endothelium, where its peculiar ionotropic properties (high Ca2+ permeability) and its supervening ...
α4β2 nicotinic receptors with high and low acetylcholine sensitivity: Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine
(2006)
α4 and β2 nicotinic acetylcholine receptor (nAChR) subunits expressed heterologously assemble into receptors with high (HS) and low (LS) sensitivity to acetylcholine (ACh); their relative proportions depend on the α4 to ...