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Modulation of androgen receptor protein by culture conditions of human skin fibroblasts
(2002)
Cultures of skin fibroblasts show variation of androgen binding with culture conditions; binding variations are usually avoided by using confluent cultures. In this work, we analysed the effect of cell density and mitogenic ...
Tumor necrosis factor-α-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts
(2009)
Background and Objectives: Membrane type 1-matrix metalloproteinase (MT1-MMP) is a collagenolytic enzyme involved in connective tissue remodeling. In periodontal tissues, either cytokines or growth factors regulate the ...
Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway
(Lippincott Williams and Wilkins, 2015)
© 2015 Wolters Kluwer Health | Lippincott Williams & Wilkins.Objective: To study whether transient receptor potential melastatin 4 (TRPM4) participates in endothelial fibrosis and to investigate the underlying mechanism. ...
In vivo and in vitro evidence of basic fibroblast growth factor action in mouse mammary gland development
(ELSEVIER SCIENCE BV, 1998-11-20)
Basic fibroblast growth factor (bFGF) stimulated [H-3]thymidine incorporation at all stages of development, although the magnitude of this effect was the greatest in cells derived from pregnant mice. Cells primed with ...
Lipopolysaccharide activates toll like receptor 4 and prevents cardiac fibroblast to myofibroblast differentiation
(Springer, 2017)
Bacterial lipopolysaccharide (LPS) is a known ligand of Toll-like receptor 4 (TLR4) which is expressed in cardiac fibroblasts (CF). Differentiation of CF to cardiac myofibroblasts (CMF) is induced by transforming growth ...
Role of nerve growth factor and its TRKA receptor in normal ovarian and epithelial ovarian cancer angiogenesis
(BioMed Central, 2014)
In normal ovarian function a controlled angiogenesis is essential. Several growth factors are involved in this process,
such as the vascular endothelial growth factor (VEGF) and nerve growth factor (NGF). The angiogenesis ...
Fibroblast growth factor-21 potentiates glucose transport in skeletal muscle fibers
(Bioscientifica, 2020)
Fibroblast growth factor 21 (FGF21) is a pleiotropic peptide hormone that is considered a myokine playing a role in a variety of endocrine functions, including regulation of glucose transport and lipid metabolism. Although ...
Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury
(Elsevier, 2018)
It is accepted that osteoblasts/osteocytes are the major source for circulating fibroblast growth factor 23 (FGF23). However, erythropoietic cells of bone marrow also express FGF23. The modulation of FGF23 expression in ...
Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression
(Elsevier, 2018)
Cardiac fibroblasts (CF) act as sentinel cells responding to chemokines, cytokines and growth factors released in cardiac tissue in cardiac injury events, such as myocardial infarction (MI). Cardiac injury involves the ...
Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children
(Springer, 2016)
Chronic kidney disease (CKD) in children is characterized by severe growth failure. The growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis in uremic animals shows a post-receptor impaired phosphorylation of Janus ...