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Insulin/NFκB protects against ischemia-induced necrotic cardiomyocyte death
(Academic Press Inc., 2015)
In the heart, insulin controls key functions such as metabolism, muscle contraction and cell death. However, all studies have been focused on insulin action during reperfusion. Here we explore the cardioprotective action ...
Effects of chronic intermittent hypoxia and polyunsaturated fatty acids on infarct size and oxidative stress markers in cardiac ischemia reperfusion
(Cardiology Academic Press, 2014)
Chronic intermittent hypoxia (CIH) induces structural and functional changes in heart, probably associated with ischemia-reperfusion (IR), a pathophysiological event linked with excessive reactive oxygen species generation. ...
Cardiomyocyte death: Mechanisms and translational implications
(2011)
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Although treatments have improved, development of novel therapies for patients with CVD remains a major research goal. Apoptosis, ...
Preconditioning tachycardia decreases the activity of the mitochondrial permeability transition pore in the dog heart
(2011)
Cardioprotection by preconditioning is a central issue of current research on heart function. Several reports indicate that preventing the assembly and opening of the mitochondrial permeability transition pore (mPTP) ...
Tachycardia preconditions infarct size in dogs: Role of adenosine and protein kinase C
(Lippincott Williams and Wilkins, 1998)
Background - Myocardial ischemic preconditioning is a well-known phenomenon, however there is scant information in regard to nonischemic preconditioning. Methods and Results - We studied in anesthetized dogs the preconditioning ...
Influence of gender on right ventricle adaptation to endurance exercise: an ultrasound two-dimensional speckle-tracking stress study
(Springer Verlag, 2017)
© 2017, Springer-Verlag Berlin Heidelberg. Background: Characteristic right ventricle (RV) remodelling is related to endurance exercise in male athletes (MAs), but data in female athletes (FAs) are scarce. Our aim was to ...
Polyunsaturated fatty acid induces cardioprotection against ischemia-reperfusion through the inhibition of NF-kappaB and induction of Nrf2
(SAGE Publications Inc., 2017)
© 2016, © 2016 by the Society for Experimental Biology and Medicine. The mechanistic evidence to support the cardioprotective effects of polyunsaturated fatty acids (PUFA) are controversial. The aim was to test cardioprotective ...
Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury
(Lippincott Williams and Wilkins, 2014)
Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
Studies on the role of apoptosis after transient myocardial ischemia: genetic deletion of the executioner caspases-3 and -7 does not limit infarct size and ventricular remodeling
(Springer, 2016)
Although it is widely accepted that apoptosis
may contribute to cell death in myocardial infarction,
experimental evidence suggests that adult cardiomyocytes
repress the expression of the caspase-dependent apoptotic
pathway. ...
Pilot study: Tobacco-attributable direct costs in two hospitais in Santiago, Chile Estudio piloto: Costos directos atribuibles al tabaquismo en dos hospitales de Santiago
(2008)
Background: Tobaceo is the fourth cause of the global burden of disease, accounting for 79.9 million loss of disability-adjusted Ufe years (DALYs) in 2001. In 2002, tobacco-attributable mortality in Chile represented 17% ...