Now showing items 1-10 of 161
ER stress signaling and the BCL-2 family of proteins: From adaptation to irreversible cellular damage
Programmed cell death is essential for the development and maintenance of cellular homeostasis, and its deregulation results in a variety of pathologic conditions. The BCL-2 family of proteins is a group of evolutionarily ...
(Society of Biology of Chile, 2002)
Cellular signaling is an area of intense research that transcends all fields of experimental biology. As such, progress in this domain will continue to have an ever-increasing impact on society in general and health-related ...
The importance of choosing a preclinical model that reflects what happens in Parkinson's disease
(Elsevier Ltd, 2019)
One of the major problems in the translation of successful preclinical results to clinical studies and new therapies in Parkinson's disease is the use of preclinical models based on exogenous neurotoxins that do not replicate ...
A search for endogenous modulators of the GABA receptor in different regions of the rat CNS
The possible existence of endogenous substances other than γ-aminobutyric acid (GABA), that can also bind to rat brain GABA receptors, has been investigated in synaptic membranes derived from whole rat brain, or from ...
Brain organoids: a next step for humanized Alzheimer’s disease models?
(Nature Publishing Group, 2019)
Young blood serum increased cellular response associated to wound healing in old rats
(American Society Cell Biology, 2017)
Crosstalk between calcium and redox signaling: From molecular mechanisms to health implications
Studies done many years ago established unequivocally the key role of calcium as a universal second messenger. In contrast, the second messenger roles of reactive oxygen and nitrogen species have emerged only recently. ...
Redox control of brain calcium in health and disease
Calcium ion is a highly versatile cellular messenger. Calcium signals-defined as transient increments in intracellular-free calcium concentration-elicit a multiplicity of responses that depend on cell type and signal ...
Prion pathogenesis is independent of caspase-12
(Taylor and Francis Inc., 2007)
© 2007 Landes Bioscience. The pathogenic mechanism(s) underlying neurodegenerative diseases associated with protein misfolding is unclear. Several studies have implicated ER stress pathways in neurodegenerative conditions, ...